Q54R74

PR
Gene name
washc4
Protein name
WASH complex subunit 4
Names
WASH complex subunit SWIP homolog
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0283355
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54R74

Entry ID Method Resolution Chain Position Source
AF-Q54R74-F1 Predicted AlphaFoldDB

No variants for Q54R74

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54R74

No associated diseases with Q54R74

3 regional properties for Q54R74

Type Name Position InterPro Accession
domain WASH complex subunit 4, N-terminal 37 - 603 IPR028191
domain WASH complex subunit 7, central domain 605 - 948 IPR028282
domain WASH complex subunit 7, C-terminal 966 - 1134 IPR028283

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endosome A vacuole to which materials ingested by endocytosis are delivered.
phagolysosome membrane The lipid bilayer surrounding a phagolysosome.
WASH complex A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
actin filament polymerization Assembly of actin filaments by the addition of actin monomers to a filament.
endosomal transport The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
endosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
phagosome reneutralization Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation.
protein localization to lysosome A process in which a protein is transported to, or maintained in, a location within a lysosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATSYSANNG QNEEYTFDAF EDGSSKLVGE QQLTKLNQFA VDYAQQIWKI EEALDETLNE
70 80 90 100 110 120
VWDINIDPVS IYNKPHEQLD LIELVKTDHK IFNKVILVFS SICNQTRILK ETAESKFYSP
130 140 150 160 170 180
LTVFGEITGE SSEGDVQIEV GKLLPFMIDL SAFVNRCYSL IRNIISQFAS IYQSQKNIHT
190 200 210 220 230 240
QFFKNVHLQA VYYSMIDIFS VLINLDSIIT QNTALDSSWG RYLRMVKSVK QEPNKYSVSG
250 260 270 280 290 300
EEDKLWQLEK LLLSLKGQLL EGFIFQSCIQ QEFDFPGVID VKGNKVLKAE FQYNVKVLWS
310 320 330 340 350 360
MFGTKIMDSS ELNLRERFPG FMGLYAFYIA LFKDITDKSF FKQVWEVTKR VPMVSINVNV
370 380 390 400 410 420
FWFPADFIQQ LMPGMIKIVG STFNHMEIRR DYLRNVDKEF SGRVKSYYLQ VSRWMVRMES
430 440 450 460 470 480
SQTRGGTLWD VSLSKVGQII QGVQLSYHIS HLLKTMIGLH MHLTAPLKSS DVRKLFQCAE
490 500 510 520 530 540
MLKSIENTFH RRSAMISAHI SMMVQQLTDI INEKLNVVRS KYAGRSNYSE IELDVIVALS
550 560 570 580 590 600
LCSDLLCGVA TNERITVVRL CLNVIYQSNI LKENDIEELR LHIKRLEFIS DIGKIVKASC
610 620 630 640 650 660
DCSILFWSRD LFPTYLQFLY QNPSQATSLQ YTLTGLKDVV SVLDKAIHVD NAKQRLIDVY
670 680 690 700 710 720
RNEMEEMIDK NIIQPLGKDV ETDLRLHIHA FLNIEEKDPF KTGIKEFGKF LELKPLRFFD
730 740 750 760 770 780
RTIDIKSRIS HYLDQTFYNL NTVALFDWKT YSEMRNMAFY KYGLQLLEVH LPGSTLEQGL
790 800 810 820 830 840
DVLEIMRNIH IFVSRYNYNL NNQIFIQRSS NSKTLNTINI THISNSIRTH GSGIMNTTIN
850 860 870 880 890 900
FAYRFLVQKF SIFSEFLFDD QIKSKLYKNI KYFRENKEQL NNMYPSELVT ELERDIRQLG
910 920 930 940 950 960
VSETGLTFLD HFRLLITHIG NAMGYIRLVR SGGLHYCSNA IKFVPDLKKI PKFQDLTSKD
970 980 990 1000 1010 1020
ALSPETIQAS TNLDSIIHNL SNNLSEGTEY FKMLVNVFAT EFRNIANQHL KNFYIIVPAL
1030 1040 1050 1060 1070 1080
ASNYIDHMIN SKDKLFKKSK AIGAEALLFT DDGFAIGLAY ILKLLDQNKD FDSLHWFDRI
1090 1100 1110 1120 1130
QLKCETDQKR MLAEANAKGI KEDQNHLAIK KIQNFQQEYE LFKYSFSGSR IFFKD