Q54QG9

PR
Gene name
uba3 (ube1c, DDB_G0283891)
Protein name
NEDD8-activating enzyme E1 catalytic subunit
Names
NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0283891
EC number
6.2.1.64: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

350-440 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54QG9

Entry ID Method Resolution Chain Position Source
AF-Q54QG9-F1 Predicted AlphaFoldDB

No variants for Q54QG9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54QG9

No associated diseases with Q54QG9

2 regional properties for Q54QG9

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 201 - 206 IPR018523
domain ICL/PEPM domain 56 - 464 IPR039556

Functions

Description
EC Number 6.2.1.64 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
NEDD8 activating enzyme activity Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.

2 GO annotations of biological process

Name Definition
protein modification by small protein conjugation A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein.
protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
METMDTSVDL PGRWIDIEKI IKRTGPFASP SFEPDTKASP NIMNGLQNDF KVLVIGAGGL
70 80 90 100 110 120
GCEILKNLAL SGFRNIDVID MDTIDISNLN RQFLFRRKDV GKSKAEVAAA FINSRITGCN
130 140 150 160 170 180
VTPHKCRIQD KDEDYYRQFK IVIAGLDSIE ARRWINGLLV NLVVVNDSGD IEPDTIIPLV
190 200 210 220 230 240
DGGTEGFKGQ ARVILPKISS CFECSLDAFP PQVSYAICTI ANTPRVPEHC IQWALLFGLQ
250 260 270 280 290 300
DATLEKPFDP KQFDNDNPDH MNWLFECAKK RAEKFNINGV TYKLTQGVAK NIIPAIASTN
310 320 330 340 350 360
AIIAAACCNE VFKFCTDSSG YLNNYMMYNG LNGVYTFTFE YEIKEGCAVC GTNLVTFEID
370 380 390 400 410 420
KSNTLSTFLE KITTDSRFQF KKPSLRSNGR NLYMQGLLHQ STVPNLEKTL SELNVQEDDE
430 440
ITITDPALPG NLAVRMRIKY TS