Q54PX0

PR
Gene name
DDB_G0284251
Protein name
Probable serine/threonine-protein kinase DDB_G0284251
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0284251
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

175-198 (Activation loop from InterPro)

Target domain

36-288 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q54PX0

Entry ID Method Resolution Chain Position Source
AF-Q54PX0-F1 Predicted AlphaFoldDB

No variants for Q54PX0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54PX0

No associated diseases with Q54PX0

8 regional properties for Q54PX0

Type Name Position InterPro Accession
domain Protein kinase domain 36 - 288 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 112 - 125 IPR001245-1
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 148 - 166 IPR001245-2
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 195 - 205 IPR001245-3
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 214 - 236 IPR001245-4
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 257 - 279 IPR001245-5
active_site Serine/threonine-protein kinase, active site 154 - 166 IPR008271
binding_site Protein kinase, ATP binding site 42 - 65 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIEINNNHNN GNGKQFPSSQ IMPDSKKKSI VKIGEYTLGE KIGRGAFGQV FKGLNGKTGE
70 80 90 100 110 120
FVAIKQIDSN KIDESSLQSV KGEVEILHKL RHNNIVKVLG VVEVQAQLNF ILEYVENGSL
130 140 150 160 170 180
RDVIEKFGPL SEELCIIYLY QMLQGLAYLH SNKVIHRDIK ASNILITKEG VIKLADFGVA
190 200 210 220 230 240
SQIDSESQLR FSVVGTPYWM APESIEISGC SSASDIWSLG STMIELLTGN PPYYTLQPMA
250 260 270 280 290 300
AMFRIVSDQH PPFPTDISKE FLDYFQQSFK KDPTQRPTAQ ELLQHPIFFT LQKVPPTLSE
310 320 330 340 350 360
LQSTLKTLNG GRSRLRTSVN SIDWGSSSST SGSSTPLSSS SSSSNIKSIV SDEDFNKLQT
370 380 390 400 410 420
TIKQQAQTIS NLSEEILILK KELKEKPKLE EQQFYKEYFM ALAISVKVNQ CYQDKTCEPK
430 440 450 460 470 480
DMQQLYEMAR SQEIPWYKLI EWIPSQLISN DNIPQLTPSS SRENISLSNS SSSIPNPNQN
490
QNQNNKSKSK KFGFFS