Q54PQ4

PR
Gene name
gefA (aleA, rasGEFA, DDB_G0284329)
Protein name
Ras guanine nucleotide exchange factor A
Names
Aimless, RasGEF domain-containing protein A
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0284329
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

276-360 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54PQ4

Entry ID Method Resolution Chain Position Source
AF-Q54PQ4-F1 Predicted AlphaFoldDB

No variants for Q54PQ4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54PQ4

No associated diseases with Q54PQ4

3 regional properties for Q54PQ4

Type Name Position InterPro Accession
domain Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic 4 - 289 IPR006075
conserved_site Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site 141 - 155 IPR017958
domain Asn/Gln amidotransferase 327 - 473 IPR018027

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
  • The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells (PubMed:20493808)
  • Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1 (PubMed:20493808)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Ras guanyl-nucleotide exchange factor complex A protein complex which is capable of Ras guanyl-nucleotide exchange factor activity.

4 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
guanylate cyclase activator activity Binds to and increases the activity of guanylate cyclase.
protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
protein kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.

13 GO annotations of biological process

Name Definition
activation of adenylate cyclase activity Any process that initiates the activity of the inactive enzyme adenylate cyclase.
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
aggregation involved in sorocarp development The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
chemotaxis to cAMP The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
negative regulation of asexual reproduction Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
positive regulation of protein kinase B signaling Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of Ras protein signal transduction Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
response to electrical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
sorocarp development The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MITPTSFEPV ELLYSKKKVN RTNWKKNVLK SNPEINNLCE RIYPINRAIQ FGKQFHPGKA
70 80 90 100 110 120
EVKQKLDKTA IIQLILQHLS TKGLKQTKQT LEKEARTTTP IVEGLNESRL VTYIRNALKD
130 140 150 160 170 180
TDRIYDLSME HTEYSKEERQ SKITEREELL FQMDLLEDED EDDGVNIWDE PTENIITEKV
190 200 210 220 230 240
HTTEYDINKS KENKDDQDDE VVKFASLNKL VEHLTHDSKH DLQFLKTFLM TYQSFCTPEK
250 260 270 280 290 300
LMSKLQQRYN CPSGHDEMAT RNIQIRVINV LKGWVDNYYS DFDDKLIAML RTFIDQIQIK
310 320 330 340 350 360
FPAPASAVNK SLTKMVEKLS PVNDSKHIFN EKTPEPMVPK NIFSNNLSIY DIDEEEIARQ
370 380 390 400 410 420
LTLIEFEIYR NIKPPELLNQ SWNKTKLKSR APNVLKMIDR FNSVSMWVAT MIIQTTKVKA
430 440 450 460 470 480
RARMMTRFIK IADHLKNLNN YNSLMAIIAG LNFSSVYRLK YTREELSAQT MRTYSDLEKI
490 500 510 520 530 540
MNSEGSFKTY RTRLQNVPPM LPYLGVHLTD LTFIDENPNN FVTDVGGKQV SLINFTKRTL
550 560 570 580 590 600
VFKIISLIQE TQVVPYNLQP VHQIQEFLLN IRSDLKAHTL DQYQQELYRE SLKREPKKAQ
RSDVL