Q54NU9

PR
Gene name
tpsB (DDB_G0284975)
Protein name
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] B
Names
Trehalose-6-phosphate synthase B, UDP-glucose-glucosephosphate glucosyltransferase B
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0284975
EC number
2.4.1.15: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

12-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54NU9

Entry ID Method Resolution Chain Position Source
AF-Q54NU9-F1 Predicted AlphaFoldDB

No variants for Q54NU9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54NU9

No associated diseases with Q54NU9

2 regional properties for Q54NU9

Type Name Position InterPro Accession
domain W2 domain 248 - 415 IPR003307
domain BZW1/2, W2 domain 218 - 408 IPR043510

Functions

Description
EC Number 2.4.1.15 Hexosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present.

2 GO annotations of molecular function

Name Definition
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate.
trehalose-phosphatase activity Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate.

2 GO annotations of biological process

Name Definition
trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.
trehalose metabolism in response to stress The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTIIQRSTSL NNIINEKLGK IIVASNTLPI TVTKFNETPL FGSPLSASRE SITSSFGMSE
70 80 90 100 110 120
PSRDRESKIQ IQINGHPFPT QSALETLKAK DEIEDWLWIG WSHCEVNEDE EPMLNQAIKE
130 140 150 160 170 180
FSPHFEHVFL NPRQFENYYK GYCKNGLWLL LHYQMNFIRM QSEWWEEYVG VNQMFAEKIA
190 200 210 220 230 240
SVWRPSDIIW IHDYHLMLVP QMLRQLLPPE ASIGFFFHAP FPSYELFRIL PNRKELLKGI
250 260 270 280 290 300
LSSNLIGFQS FEYVRHFKSS CARLLDLEVH PKGLEIFEDG STHFTKLQVY PIGVDYNDFA
310 320 330 340 350 360
KNLNLPEVSS RVESLRKIFK GKKVVVARDR LDQIEGVPRK LEVFEQLLND HPEYIGKLVF
370 380 390 400 410 420
IQIYEPTVEE GDETDEQKIL HKTVNEMVGR INGKFGKLSF NPIEYINKKI SYEELSALYK
430 440 450 460 470 480
LADIALITPI RDGMNLTSHE YVVCQKDNFG VLILSEFAGA ARCLGGSIIV NPFSKKEIME
490 500 510 520 530 540
AIIEALNMSM HDRKLKHQIN YNYVLANTSS FWGKRFLCDL NEATQKEIME TSVPRANFQE
550 560 570 580 590 600
IEDSYKKAKV RVFFLDYDGT LTPLVRLPSQ AMPSKQLIDV LSKLTEDRRN EVYVISGRDR
610 620 630 640 650 660
SSLEKWLGHL PIGMSCEHGV FTRQPGENQP WTESPNAEVQ WKDTVLSIMQ DFEDRTPGSM
670 680 690 700 710 720
TETKQVNITW HYRNADPDFG QFQAKELIAQ LRSVANKYPL DILSGKKAIE VKPIGINKGE
730 740 750 760 770 780
IVKMILQKID ADFILCIGDD KTDEDMFKAL YNVPSFTIRV CGDLEESTKA RGVVESSSEV
LTLLNRLSLS