Q54ML1

PR
Gene name
nadsyn1 (DDB_G0285877)
Protein name
Glutamine-dependent NAD(+) synthetase
Names
NAD(+) synthase [glutamine-hydrolyzing]
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0285877
EC number
6.3.5.1: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

665-713 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54ML1

Entry ID Method Resolution Chain Position Source
AF-Q54ML1-F1 Predicted AlphaFoldDB

No variants for Q54ML1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54ML1

No associated diseases with Q54ML1

1 regional properties for Q54ML1

Type Name Position InterPro Accession
domain Cytidyltransferase-like domain 30 - 185 IPR004821

Functions

Description
EC Number 6.3.5.1 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.
NAD+ synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.

1 GO annotations of biological process

Name Definition
NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTVTLATCN LNQWAMDFKG NLERIIESIN IAKSKGAKYR LGPELEICGY GCEDHFLEQD
70 80 90 100 110 120
TMLHCWQSLA VILKDPELTK DILVDVGMPV LHKDVRYNCR VILLNQKIYL IQPKKAMAMD
130 140 150 160 170 180
GNYREGRWFT PWIKPRVVET FYLPRIISQI TGQDECQIGD AIISTLDTAI SSETCEELFT
190 200 210 220 230 240
PNSPHIQMGL DGVEIFTNGS GSHHQLRKLD TRVDLIRSAT SKSGGIYLYS NQQGCDGSRL
250 260 270 280 290 300
YYDGSCMIMI NGDCVSQGSQ FSLVDIEVIT ATVDLEDVRS VRASFMARCA QANLTKEFPR
310 320 330 340 350 360
VRCPIQLTHI DYCHPPDRVI HINYNTPAEE IGFGPACWLW DYLRRSGLSG YFLPLSGGAD
370 380 390 400 410 420
SAATAAIIGI MCQLVILDVS KGNKQVLKDA QRITNSPEDY IPTDSREFAS RLFFTAYLGS
430 440 450 460 470 480
KNSSKETRDR AMEIAKDIGS VHKEVDIDDI SQSFNDAFSQ ITKKQPQFRA HGGTPRENLA
490 500 510 520 530 540
LQNVQARTRM VLSYHLASLL LWEQGRPGSL LVLGSANCDE SLRGYMTKYD CSSADINPIG
550 560 570 580 590 600
GMSKIDLRSF IEWAGKFRDM KSILSVLTAT PTAELEPITE NYTQSDEIDM GMTYEELSIF
610 620 630 640 650 660
GKLRKVNRCG PVSMFERLVA DWAHLEPSVV AEKVKRFFYY YAINRHKLTT LTPSYHAEGY
670 680 690 700 710
SPDDNRYDHR QFLYNSKWDV QFETIDKIVL RLSQRPQLKN TVNCPNQASL TQQ