Q54J66

PR
Gene name
thrS1 (DDB_G0288267)
Protein name
Probable threonine--tRNA ligase 1, cytoplasmic
Names
Threonyl-tRNA synthetase, ThrRS
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0288267
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54J66

Entry ID Method Resolution Chain Position Source
AF-Q54J66-F1 Predicted AlphaFoldDB

No variants for Q54J66

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54J66

No associated diseases with Q54J66

7 regional properties for Q54J66

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 320 - 528 IPR002314
domain TGS 1 - 61 IPR004095
domain Anticodon-binding 540 - 628 IPR004154
domain Aminoacyl-tRNA synthetase, class II 242 - 533 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 169 - 218 IPR012947
domain Threonine-tRNA ligase catalytic core domain 242 - 538 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 538 - 627 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDSQENKPV ETPTEVKPVA EKKPAAEKKE KKPAVKKVGV METLQTPDYV KERIEIWESL
70 80 90 100 110 120
KAKHLESLKD MKEEPINVTL PDGKVVAGIK NKTTPYDIAK GISRGLADSI VSSKVNGEQI
130 140 150 160 170 180
WDISRPLEAD CNLQLCKFDS EEGKKTFWHS SAHILGQAME RIYGGQLCIG PATSEGFYYD
190 200 210 220 230 240
MAMGDKIVSA EDYKLINEVA QKIVQEKQPF ERLAVPRDIA LTMFKFNKYK TEIISKIPQE
250 260 270 280 290 300
DTVSLYRCGT LVDLCRGPHV PNTSYIKSFA VTKNSSAYWL GKAENDDLQR VYGISFPDKK
310 320 330 340 350 360
QMEEYENFMR EAALRDHRNV GKAQELFFFH PYSPGSAFFL PHGTRIYNKL VEFIREEYHR
370 380 390 400 410 420
RGFTEVISPS IFSQKLWEQS GHWQKYSENM FVLPVDKDNF SLKPMNCPGH CLMFGSRQRS
430 440 450 460 470 480
YRELPLRFAD FGVLHRNELA GALTGLTRVR KFQQDDAHIF CTTEMIEDEI NSCLGFMQYV
490 500 510 520 530 540
YGIFGFEFGL ELSTRPDNFL GEIAQWDIAE ASLEKALNKF GKPWKLNPKD GAFYGPKIDI
550 560 570 580 590 600
HITDCLKRSH QCATIQLDFQ LPIRFDLEYQ SDDAAELKKR PVIIHRAILG SVERMMAILI
610 620 630 640 650 660
EHTGGKWPLW VSPRQAIVVT VNKTHNEYGQ KVCKEISDAG FYCDIDDSDK TISKKVREAQ
670 680 690 700
LAQYNYILVV GQEEINGNTV NVRTRDNVVR GSLTVNDLIS EFKQLVKEFK