Q54IP4

PR
Gene name
shkB (DDB_G0288617)
Protein name
Dual specificity protein kinase shkB
Names
SH2 domain-containing protein 2, SH2 domain-containing protein B
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0288617
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-180 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

315-323 (Activation loop from InterPro)

Target domain

174-432 (Protein kinase domain)

Relief mechanism

Assay

335-339 (Activation loop from InterPro)

Target domain

174-432 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q54IP4

Entry ID Method Resolution Chain Position Source
AF-Q54IP4-F1 Predicted AlphaFoldDB

No variants for Q54IP4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54IP4

No associated diseases with Q54IP4

5 regional properties for Q54IP4

Type Name Position InterPro Accession
domain Protein kinase domain 174 - 432 IPR000719
domain SH2 domain 534 - 608 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 177 - 428 IPR001245
active_site Serine/threonine-protein kinase, active site 294 - 306 IPR008271
binding_site Protein kinase, ATP binding site 180 - 202 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

1 GO annotations of biological process

Name Definition
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNDKISKLES SILQLTEEVK QLESKQASKE LEIRTLVDNA INSQNPAQER ELINKLFTES
70 80 90 100 110 120
LIDLKLKAEK IQTLERYRQE IITNLLVEQK QPNDTSIISA WEQLKISSFR INPNNNNNNS
130 140 150 160 170 180
NNTNSSDSNQ NYSSVILNGS LTEDSTSTIS PDSTKNRDEE EIIRWEIDRN EISYNREAKL
190 200 210 220 230 240
GSGAFGSVYK GIVRGKEVAI KKLTQTVFEE NTMNEFKKEV SLMAKLRNPH LLLFMGACTA
250 260 270 280 290 300
PEDLSIVTEL MPKGSVHSLL RAKEDTSDFI TFKRAILIAR DTVLGMTWLH ASNILHLDLK
310 320 330 340 350 360
PANLLVDQNW VVKVADFGLS KYMKPDSKDK LLGQAGSPLY MAPEMLVNQP YDGKVDVFSF
370 380 390 400 410 420
SILLWELLTK QEPYNKLYSS YPQLVEGVVN KKNRPIIPDY FPTRLKDLLA RCWDHYPSRR
430 440 450 460 470 480
PSFAEISKQR ILETILIDGL ILDSSARQFW SQYYMGKEEV PWNSFIVNFS LYCGFESNLS
490 500 510 520 530 540
ADDIKIKFLK LLLVPVDSDM VTIDNFGKIL TWVGPLTNGR EFFDKVYSIC SIKGFMAATS
550 560 570 580 590 600
SKNASQYLAG KKTGTYILRF SSDPGSYAIS YLNKNKEIIH ARVIYKQGSG YIHHGGQTHY
610 620 630 640 650
ATLDDLIKNT FKSLGIKEPF EGGPFHALTV AASSSKPFNI AGAYIPVAPS KKI