Q54I81

PR
Gene name
eif2b1 (DDB_G0288961)
Protein name
Translation initiation factor eIF-2B subunit alpha
Names
eIF-2B GDP-GTP exchange factor subunit alpha
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0288961
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-150 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54I81

Entry ID Method Resolution Chain Position Source
AF-Q54I81-F1 Predicted AlphaFoldDB

No variants for Q54I81

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54I81

No associated diseases with Q54I81

No regional properties for Q54I81

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q54I81

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
eukaryotic translation initiation factor 2B complex A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.

1 GO annotations of molecular function

Name Definition
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
regulation of catalytic activity Any process that modulates the activity of an enzyme.
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTGGLNKDFD WVVAKFEEMI KRETEVSIAI PTIRILIDVI RKSNSTTVVG LQKELEDAVK
70 80 90 100 110 120
QLKSCPYNQS ISLSSVCDSF IRFVTKRTEL DFPNFDTCKS NLVERGEQLS NKSSMSRTKI
130 140 150 160 170 180
SQLADKFIRD GVTILVHGFS RVVLGLLLHA AFQGKRFSVI VTESRPDSSG YKTAARLQAA
190 200 210 220 230 240
NIPVKLIMDG GVSRIIDKVD YVLVGAEAIV ENGGIVNKIG TYQISIVAKA FKKPFYVAAE
250 260 270 280 290 300
SFKFTRSYPL NQSDIENLKN DHISEPFKAC RSCSSCENPE QLTIDSPTLD YTPPSYITLL
310 320
FTELGVLTPS AVSDELIKLY C