Q54HS9
Gene name |
apm1 (DDB_G0289247) |
Protein name |
AP-1 complex subunit mu |
Names |
AP-1 adaptor complex mu1 subunit, Adaptor protein complex AP-1 subunit mu, Adaptor-related protein complex 1 subunit mu, Clathrin-adaptor medium chain Apm1, Mu1-adaptin |
Species |
Dictyostelium discoideum (Slime mold) |
KEGG Pathway |
ddi:DDB_G0289247 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q54HS9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q54HS9-F1 | Predicted | AlphaFoldDB |
No variants for Q54HS9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q54HS9 | |||||
No associated diseases with Q54HS9
4 regional properties for Q54HS9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Clathrin adaptor, mu subunit, conserved site | 158 - 178 | IPR018240-1 |
| conserved_site | Clathrin adaptor, mu subunit, conserved site | 257 - 271 | IPR018240-2 |
| domain | AP complex, mu/sigma subunit | 4 - 130 | IPR022775 |
| domain | Mu homology domain | 158 - 426 | IPR028565 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| AP-1 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). |
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| clathrin adaptor activity | Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| endosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. |
| hypotonic response | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| lysosomal transport | The directed movement of substances into, out of or within a lysosome. |
| sorocarp development | The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAASAIFLMD | SKGKVLISRN | YRGDVPMSVA | SKFISKILEE | EDLNLKPIIQ | EDGISYIYVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HNNLFLLATT | ERNANAATIL | LFLYKMIEVF | NEYFKELEEE | SIRDNFVVIY | ELMDEMMDFG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YPQSTEPKIL | QEYITQEGYK | LERGARGMVL | PAAITGAVSW | RKEGIKYNKN | EVFLDVVESI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NLLVSANGTV | LRSEIVGAVK | MKSKLSGMPE | LRLGLNDKIL | FENSAKTGAP | KGKGVELEDV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KFHQCVRLSK | FENDRTISFI | PPDGEFELMS | YRLNTTVKPL | IWVECISDTH | AHSRVEYMVK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AKSQFKGKSI | ANNVEIIVPV | PPDADTPKFR | CTVGTCKYAP | EKDAIIWTIK | QFPGGGREFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MRAHFGLPSI | SDEKPATKPP | IMVKFEIPYY | TVSGIQVRYL | KIIEKSGYQA | LPWVRYVCLS |
| GDYQFRTS |