Q54G43

PR
Gene name
shkE (DDB_G0290451)
Protein name
Dual specificity protein kinase shkE
Names
SH2 domain-containing protein 5, SH2 domain-containing protein E
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0290451
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

140-235 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

376-384 (Activation loop from InterPro)

Target domain

237-495 (Protein kinase domain)

Relief mechanism

Assay

397-401 (Activation loop from InterPro)

Target domain

237-495 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q54G43

Entry ID Method Resolution Chain Position Source
AF-Q54G43-F1 Predicted AlphaFoldDB

No variants for Q54G43

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54G43

No associated diseases with Q54G43

6 regional properties for Q54G43

Type Name Position InterPro Accession
domain Protein kinase domain 237 - 495 IPR000719
domain SH2 domain 597 - 707 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 241 - 490 IPR001245
active_site Serine/threonine-protein kinase, active site 355 - 367 IPR008271
binding_site Protein kinase, ATP binding site 243 - 268 IPR017441
domain ShkD/ShkE, SH2 domain 586 - 672 IPR035845

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDINLIKQYI NSSLPNDKES LIQYYGQLKQ ILNALSDKEQ QQLLNNNGKI SEQQQLSIEN
70 80 90 100 110 120
NYKVIGSIEE KMKSIEHLFN NLDVSDSNNN NSTSPVFISL DNQNTVNNNN NNNNNNNNNN
130 140 150 160 170 180
NNNNNNNNNS LAPTVILDNN DNKKTAEIIL PDHHNNTPQQ QPEQQVQQQQ VQQQQQVQQQ
190 200 210 220 230 240
QQQPEQQQQH LTEEQIQKQQ QSQASIQQAI ANMGEKKRSS SRHSGPPEIP PEEIKFDVKT
250 260 270 280 290 300
DLLGGGAYGK VYKATCRGKK VAVKVPKKQT LSESELKSFK NEVEIMKQIF HPNVVLCLGA
310 320 330 340 350 360
CTKPGKVMIV SELMQTDLEK LIHSSEVEPP PLYERMKMCL DAALGINWLH GICNIIHRDL
370 380 390 400 410 420
KLANLMISKD KTVKIGDFGF SQVIKTGTTL SDQKGPKGTA LYMAPEVMMK HEFNEKADVY
430 440 450 460 470 480
SFGLILYEMA TCEELFPEYS EIDPFYDAIC NKKLRPPIPD SFPKSLKTLI QKCWDHDPNK
490 500 510 520 530 540
RPSFNEVTQR MNEVLTDTAI SGLDAAMFWK YNFIKPESES VPWNEFVYKL SSVVNLPTQV
550 560 570 580 590 600
LSPLAQLFVS QSYEEEIGGV VTMERFDLMN KWFGNFFNSK YGPAILYEMI ELLKKRWFHF
610 620 630 640 650 660
DISRDISEKR LRGRPENTFL LRLSANDPIK TPFTISKTKG SKPTHKRVSR EDVQINEIKQ
670 680 690 700
FPMGYKFTVP LDGNELVFGS ITQMVEELHR IGNLSIPCPI TEIKVPYLTD