Q54EW3

PR
Gene name
DDB_G0291650
Protein name
Probable importin-5 homolog
Names
Importin subunit beta-3, Karyopherin beta-3
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0291650
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54EW3

Entry ID Method Resolution Chain Position Source
AF-Q54EW3-F1 Predicted AlphaFoldDB

No variants for Q54EW3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54EW3

No associated diseases with Q54EW3

3 regional properties for Q54EW3

Type Name Position InterPro Accession
repeat HEAT repeat 395 - 425 IPR000357
domain TOG domain 352 - 581 IPR034085
repeat Importin repeat 4 266 - 338 IPR041653

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
nuclear import signal receptor activity Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
nuclear localization sequence binding Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.

1 GO annotations of biological process

Name Definition
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLQPITDLL KALNSGNTTT IQQAEQLYAD YKNHQPDQLV NSFIVLIRTS QDELLRSYPP
70 80 90 100 110 120
VLLRTLVNGN DSGNILKGLK PETLVTLKTE LMFAVREEPK NHIRHSILNV IAILAIQLVP
130 140 150 160 170 180
EQKWPEILSF IIESSSSPEE NLRESSFYLI GAIIDDSRVA ETLAPHFDKF ALLVEKGLND
190 200 210 220 230 240
PSAKVQVSAL ETVSTFIDAN PEKAEVFKPL IPAMLNTIQK TIESNLEKEA QKGILTFIII
250 260 270 280 290 300
AQYHSDWFKT NFDMIFKVFF QFLEHQSLED ETKHACLHFF LTFAEFKSSI MKKKLYLEPI
310 320 330 340 350 360
VLLLLKWMSS VEDMDLKDWN SLDTEPSDDD DSNVAFEAIE ALSHCVSKGL WEFFLQCAPT
370 380 390 400 410 420
LLNSGNWKER YTGLMTLSSI SEGCEKQIKT NFKLIIQSIL PLANDSHPRV RFAFFYCLGS
430 440 450 460 470 480
FASYLKREMQ DLYKTLIPVS LEHLNDPFPR VTISNCEFLT LFLDEIKPNR VKEFKDQFLG
490 500 510 520 530 540
RLSPLLQNEN YKIVQHSLNA FSSVVDGIGE EFTQHYSEIM PFLIKILRTQ TSVETKTLRG
550 560 570 580 590 600
RAIETISLVG LAVGKKVFLN DCIQIIQYVS SLEKFKDDDP QVDFFLRAFT RFAQCLGEDF
610 620 630 640 650 660
IPYLKYSMSP LMDAINGKVD SSVENGEDFS DESNNSGSIV MENKAMALEM VSIYAMELKH
670 680 690 700 710 720
HLFPYVEQLY KGSIELVDFP FSSLVAIQAV NLIPFLVKIS KQHFEAVGGL KDGMKAEFTS
730 740 750 760 770 780
RLFLDSYERM AASIKTESEP DTLSAKLKAL SDLMDIGGQC EQADRILSLT FEVANESFGT
790 800 810 820 830 840
LQELETEYQE NIDEEDEDAD ESPEREIIDD AYNSLAMVLG EVCIQFKEKA VPYIATVLPA
850 860 870 880 890 900
MIELIETAPS VEIKTSMICI LDDLIENGGQ KAFELYPHII KPMMNCTLPN LDPSLIQSAV
910 920 930 940 950 960
FGIGLAAENG KDYFTPFLME SLQLINNVIV SVNSVQEQDD DLIAARDNAI SAMGRIITNL
970 980 990 1000 1010 1020
PQHLGNNFPQ TIALWLSYLP IQDDGEAGSI IKSLCTLIRD FSQQIMTQQY IVKVLEIIAV
1030 1040 1050 1060
GLHKKAVNPD DKQIISLALR SQESLVAQSL FQLSAENQAI LANFFKN