Q54EW2

PR
Gene name
DDB_G0291301
Protein name
Putative bifunctional amine oxidase DDB_G0291301
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0291301
EC number
1.4.3.2: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

169-242 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54EW2

Entry ID Method Resolution Chain Position Source
AF-Q54EW2-F1 Predicted AlphaFoldDB

No variants for Q54EW2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54EW2

No associated diseases with Q54EW2

2 regional properties for Q54EW2

Type Name Position InterPro Accession
domain Amine oxidase 515 - 1002 IPR002937
domain FAD dependent oxidoreductase 10 - 390 IPR006076

Functions

Description
EC Number 1.4.3.2 With oxygen as acceptor
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
L-amino-acid oxidase activity Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.
L-pipecolate oxidase activity Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
polyamine oxidase activity Catalysis of the oxidative degradation or interconversion of polyamines.
sarcosine oxidase activity Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2).

1 GO annotations of biological process

Name Definition
cellular amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MREFLKDDYD VIVCGGGPVG LATAYRCAKA GKKVLCLEKS VFFNGGGSSG DVVRMLRTMY
70 80 90 100 110 120
TEDYMADLAH ETLGLWKELG DDAGEGDLVW MTGLLNFGDP NYGAGGPEGT LLGPIPNLER
130 140 150 160 170 180
LGMQYKVLTA QEIMEEYPFR NIPSNHQGVF APDNGVINLP LVLRSLYKLC LQYGCKMVSH
190 200 210 220 230 240
AEVKLIKNLS TTMVEIEVEH TDVDQKNKQS FKVKSKKAAI TSNSFCNHII KPSFGWELDM
250 260 270 280 290 300
TIWEMTSSYF VAKPGPNATV FKSMWFNFQN DTDNDPTKSN LYYGFPAVPW MTDNHCRIAL
310 320 330 340 350 360
DAALRQIKDP NDRHDGVETH DVNRTRDWVR EHIPGVDDTP LFNVSALMAN VYDNMFVLDF
370 380 390 400 410 420
IPETNNNVVM FACGWAMKFI PLLGKILSQL LDEGKTQYPI DHFALNRGNG ALIIKEGQTP
430 440 450 460 470 480
KSVNSQVRAP RYTSMHCKPL TIAKSTVPTN QSSNPDGASS TAPTQSLRSL FASRLLQRSV
490 500 510 520 530 540
GMEAKFHSII AKNRSKRSTK ASQKDLTVGI IGAGMAGLYA AMILQDLGLQ YNILEANKER
550 560 570 580 590 600
VGGRIYTYRF PQNQDKYQTV ELGAMRFPKI EIMDRLLNLD KPWSLFSKLE KAGHKIPTIP
610 620 630 640 650 660
YHLTVDNNLV YYNGKRIFAN TLLNDDPLYF SDTHNGGPGT AVPDKYTYQP YGDLLDAVYK
670 680 690 700 710 720
KFSDDLENDF ESGFETLLKS DNYSTRAYLF EKGPYPQSVV NYLETMDTGT GLYDMAFSET
730 740 750 760 770 780
IMDYFDFSAG DEWLCIDGGT DIIVNSMVKT LRPGCIEQGK VVTKVSRVVG KSGDVSNLKV
790 800 810 820 830 840
DFLDGTEGRL FKHVISTGTL ASLRRVDLSD LKLSHNKRTA IRSLHYDHSV KIALSFKSRW
850 860 870 880 890 900
WEDSKFMNGK PMLGGKSSTD LPVRTIVYPS YGIGQPGVSG VLIVSYTWSL DASRIGSLVG
910 920 930 940 950 960
DRPSEEVLIK LCMANLAEVH NVPVATLQQL FVDYKCWDWY NDDYSSGAFA LYSPSQFSQL
970 980 990 1000 1010 1020
FPSLTKPSPD GRFHLAGEAT SVHHGWVIGS LNSAYRSVDH ILQVEGLDEL RAKLRLNWGF
1030 1040 1050 1060 1070
IDEVEDPQDD QQYVDPHHNL SGPNAKKFRS NVSQVAIQPR FKAPRNFKPR NTAASIGGLK