Q54ED3

PR
Gene name
dnaja1 (DDB_G0291568)
Protein name
DnaJ homolog subfamily A member 1 homolog
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0291568
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

368-437 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54ED3

Entry ID Method Resolution Chain Position Source
AF-Q54ED3-F1 Predicted AlphaFoldDB

No variants for Q54ED3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54ED3

No associated diseases with Q54ED3

4 regional properties for Q54ED3

Type Name Position InterPro Accession
domain Heat shock protein DnaJ, cysteine-rich domain 158 - 243 IPR001305
domain DnaJ domain 5 - 84 IPR001623
domain Chaperone DnaJ, C-terminal 144 - 366 IPR002939
conserved_site DnaJ domain, conserved site 50 - 69 IPR018253

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Lipid-anchor
  • Cytoplasm
  • Microsome
  • Mitochondrion
  • Nucleus
  • Cytoplasm, perinuclear region
  • Primarily cytoplasmic and associated with microsomes
  • A minor proportion is associated with nuclei and mitochondria (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
metal ion binding Binding to a metal ion.
unfolded protein binding Binding to an unfolded protein.

2 GO annotations of biological process

Name Definition
protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVKEKEYYER LGVKPDCTED ELKKAYRKMA VKYHPDKNQG PGKDAAEAKF KDISEAYEVL
70 80 90 100 110 120
SDPEKRKMYD SYGSEGMKES GFHASSAEDL FSHFFGAGGG GGGFSFGGGG GDDFGGFSFG
130 140 150 160 170 180
NMGGMGGMGG MGGGHKKRRK GEDIEHEMNR SLEELYNGKL VKISISRDEV CKTCKGSGSN
190 200 210 220 230 240
KPGVTTTCPT CNGSRYVFQK KQVGPGMIQQ VQTACHTCHG TGEKIKEEDK CKECKGKRVI
250 260 270 280 290 300
QGKKIVQFQV EKGTRDGERI MLQGQGSEYP GVPPGDVIIT IREKPNVNFK RNGDNLIYTK
310 320 330 340 350 360
RLKLLDSIAG SQFIINTLDQ RKLWVNHEKG DIIKQGDMRY IENEGMPIKG TSRKGKLIIA
370 380 390 400 410 420
FDIEYPSNLT NDDIEKLSKI LPKAATPSVS KSDCKSVGLS KVNFNTNEQS SHGGAGGAYQ
430 440 450
QHGGAYGHQK QQQQGFNPAD FGAQFGGGGP QQAQQCQQQ