Q54E36

PR
Gene name
xpo2 (DDB_G0291838)
Protein name
Exportin-2
Names
Exp2, Importin-alpha re-exporter
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0291838
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-124 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54E36

Entry ID Method Resolution Chain Position Source
AF-Q54E36-F1 Predicted AlphaFoldDB

No variants for Q54E36

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54E36

No associated diseases with Q54E36

3 regional properties for Q54E36

Type Name Position InterPro Accession
domain Importin-beta, N-terminal domain 29 - 104 IPR001494
domain Exportin-2, C-terminal 532 - 943 IPR005043
domain Exportin-2, central domain 161 - 531 IPR013713

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

2 GO annotations of molecular function

Name Definition
nuclear export signal receptor activity Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
small GTPase binding Binding to a small monomeric GTPase.

2 GO annotations of biological process

Name Definition
protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELPKETIEQ LQNLFIAANR PEKEIREEAT SKIQKFVKET PNSIITLLVF QNLKTIDAGA
70 80 90 100 110 120
RTLSAITFKN LVKDSWVDGD EVENPIPSND KEMVKSLLLN FILSAVNNTT QSQLVESLSM
130 140 150 160 170 180
IGVSDFPQQW PSILPELIKQ MESNTDIPTL SIILRVLHSL LKKYRGQERN NQSLSELKYI
190 200 210 220 230 240
LSILPTPYLS LLIKTGVAVD ANLQNEQQLV LLLNCVHFLL EIFFSMSSVD LPEFFEDNLA
250 260 270 280 290 300
SFTNEFHRYL KFNTNFQSII LSSNDEEPSL LKKIQTSICE IINLYTQIYD EEFSSFLQPF
310 320 330 340 350 360
VQVVWGLLTQ TSKDICNDPF VYASIRFLGT VATSISHKIF ESPETLKQIC SMIVTPNIEL
370 380 390 400 410 420
RESDIELYED NHVEYMRRDI EGSDSDTRRR AAIELVKGLR KYYENQVIQL LSVDINNLLQ
430 440 450 460 470 480
KYNSNREENW ICKDSAIFLV TALAVKSGGS DESSESSKLV NVLDFFKSSI EPELSGATQT
490 500 510 520 530 540
NKPILKADCL KFITIFRNQI PAEEYPRILQ SVIPCLENPD FIIHTYASTC IDRLLSVKDG
550 560 570 580 590 600
GVPRLSAEFI STNLTGLLLP LVGVFNFKDS KQNERAMRTI VRIVLMTQGK VSQQITIQLL
610 620 630 640 650 660
QKFVSIIIEE AKNPSNHSFN HYCFEVVGTL LKGFSSEPEV TQIIMPLIEM VLQTNNAEFS
670 680 690 700 710 720
PYCFQLLSIL VENCRPEYLD LFRPILPIIF NDMTWARDAD YPALVRLLQA FIKKEGSSIA
730 740 750 760 770 780
PHLSAILGIT EKLIMRVTHD HEAFLILETV VETLDIQFLE KYLGGIFSMI LTRITKKKTL
790 800 810 820 830 840
KVVRCFTIFF SIFMIKYGVV KTAQTVRAIK DSLWEDILIK LWLPTVEDIN GSIEKKIISI
850 860 870 880 890 900
SLTNMICCND ILATPELWIK LIQCQSNVIS GKKSQETEQA GAASDLYIDQ AEANEGYVPT
910 920 930 940 950
FTQLQFSKKV DVDPFPTISN PKEYFISTFQ TFKSQNEMLV TPLLSTANIQ L