Q54E04

PR
Gene name
vatM (DDB_G0291858)
Protein name
Vacuolar proton translocating ATPase 100 kDa subunit
Names
Clathrin-coated vesicle/synaptic vesicle proton pump 100 kDa subunit, Vacuolar ATPase transmembrane subunit
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0291858
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-124 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54E04

Entry ID Method Resolution Chain Position Source
AF-Q54E04-F1 Predicted AlphaFoldDB

No variants for Q54E04

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54E04

No associated diseases with Q54E04

No regional properties for Q54E04

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q54E04

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle membrane; Multi-pass membrane protein
  • Endosome membrane; Multi-pass membrane protein
  • Vacuole membrane; Multi-pass membrane protein
  • Lysosome membrane; Multi-pass membrane protein
  • Found in membrane of contractile vacuole complex, an osmoregulatory organelle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

12 GO annotations of cellular component

Name Definition
contractile vacuolar membrane The lipid bilayer surrounding the contractile vacuole.
early phagosome A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
endosome membrane The lipid bilayer surrounding an endosome.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
pathogen-containing vacuole A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle.
vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
vacuolar proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

2 GO annotations of molecular function

Name Definition
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

3 GO annotations of biological process

Name Definition
phagocytosis, engulfment The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
regulation of intracellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
vacuolar acidification Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFLRPSIWR SSPMQMVQLF VQIEAAHDTV DELGKLGLIQ FLDDNEHVNL FQRNFVNEVK
70 80 90 100 110 120
RCDDMEKKLK FFEDQVKKEP KLQKLLPDNM LSVVDDDSQM DELEGRFDEL ESELKQVNAN
130 140 150 160 170 180
QETLQRNYNE LIQLRHVLTK DSVFFQENPN LIEGEGHEHS ARSPLLAEDQ HVSEVAKQGV
190 200 210 220 230 240
KLGFITGVMN TDKMPQFQRS LWRTTRGNNY VKDARIEEEI IDPQTGEETA KTVFIVFFQG
250 260 270 280 290 300
ERLQQKIKKI CESFGANIYD CPDNSFERSN LLQKVTVRIT DLYEVLQRSK DHKRQTLAGI
310 320 330 340 350 360
VPRLYSWKKK VLLEKSIYHT MNLFDYDVGR KCLIAKGWTP KDKIEEIQLA LRTATTRSGA
370 380 390 400 410 420
LVPSVLSIIK TEGSPPTHFE TNKYTSSFQE IVNAYGIAHY REVNPAVLTI VTFPFLFGVM
430 440 450 460 470 480
FGDVGHGALL LLSALGLISL EKKLAGKKLN ELIQMPFDGR YVLFLMSLFS IYVGFIYNEC
490 500 510 520 530 540
FSIPMNIFGS QYNLNSTTGL YTYQHTDRVY PVGVDPLWKG APNELVYYNS FKMKLSIIFG
550 560 570 580 590 600
VVQMSVGICF SLLNYLNQKG PIKIVNILTQ FVPQMIFLWS IFGYMSVLII LKWVVPYRSF
610 620 630 640 650 660
EVDKVDPPFI LPTIIAMFLS PGGTPDVVFF SGQGAVQTAL LFLALISIPV MLVIKPLFMK
670 680 690 700 710 720
RFHFQEVERK KLGHHEEEHD DEALYTGHHG EEFEMGEVFV HQVIHTIEFV LGAVSNTASY
730 740 750 760 770 780
LRLWALSLAH SELSSVFWER ILIGQVERGN PFLAFVGFGA WLGASVAVLL LMESLSAFLH
790 800 810
ALRLHWVEFQ NKFYIGDGVR FIPYSATRIL SEDDE