Q54DS8
Gene name |
sec13 (DDB_G0292052) |
Protein name |
Protein SEC13 homolog |
Names |
GATOR complex protein SEC13 |
Species |
Dictyostelium discoideum (Slime mold) |
KEGG Pathway |
ddi:DDB_G0292052 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q54DS8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q54DS8-F1 | Predicted | AlphaFoldDB |
No variants for Q54DS8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q54DS8 | |||||
No associated diseases with Q54DS8
6 regional properties for Q54DS8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 2 - 40 | IPR001680-1 |
| repeat | WD40 repeat | 44 - 85 | IPR001680-2 |
| repeat | WD40 repeat | 91 - 132 | IPR001680-3 |
| repeat | WD40 repeat | 137 - 193 | IPR001680-4 |
| repeat | WD40 repeat | 198 - 241 | IPR001680-5 |
| repeat | WD40 repeat | 249 - 285 | IPR001680-6 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| COPII vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| nuclear pore | A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. |
| nuclear pore outer ring | A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| COPII-coated vesicle budding | The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle. |
| endoplasmic reticulum to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. |
| mRNA transport | The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of TOR signaling | Any process that activates or increases the frequency, rate or extent of TOR signaling. |
| positive regulation of TORC1 signaling | Any process that activates or increases the frequency, rate or extent of TORC1 signaling. |
| protein exit from endoplasmic reticulum | The directed movement of proteins from the endoplasmic reticulum. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATQNVDSGH | EDMVHDAQFD | YYGKFLATCS | SDKMIKIFDV | GGENPQHLVD | LRGHEGPVWQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VAWAHPKFGK | ILASASYDRK | VIVWKEVGNN | SWSIIHQYAG | HELSVNSISW | APHEFGLSLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CASSDGSVTI | HNYNNNVWEA | PQKIQVSQIG | VNSVSWSPAA | IPTSLVNSAN | TIIPAPIKRI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTGSCDNLIK | IFKNVEDKWI | LDKQLEDHKD | WVRDVAWAPN | IGLPYSKIAS | CSQDRSVIVW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TQDENGVWSG | KPLPKFDDIV | WRVSWSVIGN | ILAVSCGDNQ | VTLWKEGVDS | EWKLISHVEN |
| N |