Q54DF9

PR
Gene name
hemE (urod, DDB_G0292294)
Protein name
Uroporphyrinogen decarboxylase
Names
UPD, URO-D
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0292294
EC number
4.1.1.37: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

307-364 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54DF9

Entry ID Method Resolution Chain Position Source
AF-Q54DF9-F1 Predicted AlphaFoldDB

No variants for Q54DF9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54DF9

No associated diseases with Q54DF9

3 regional properties for Q54DF9

Type Name Position InterPro Accession
conserved_site Flavodoxin, conserved site 5 - 21 IPR001226
domain Flavodoxin/nitric oxide synthase 3 - 172 IPR008254
domain Flavodoxin domain 4 - 152 IPR026816

Functions

Description
EC Number 4.1.1.37 Carboxy-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

1 GO annotations of molecular function

Name Definition
uroporphyrinogen decarboxylase activity Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2.

2 GO annotations of biological process

Name Definition
heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEENINKNE FPELKNDTFL KACRGEEVPY VPVWIMRQAG RYLPEFKSVR ADVDFFSVCR
70 80 90 100 110 120
TPELACKVTL QPLDRFPLDA AIIFSDILVV PQAMGIEVQM IPGKGPFFPN PIRTIEDLSR
130 140 150 160 170 180
VQFPVDVNKE LGYVFDALTL TRKRLEGRVP LIGFTGAPWT LMTYCIEGSG GTTMSNSKSW
190 200 210 220 230 240
LYKHPAESHK FLSMLTRVCI DYLLGQIKAG AQALQIFDSW SNELSPAMFK EYCLPYLVQI
250 260 270 280 290 300
GKEVKAVHPE IPLICFAKGS NFALEDLSKS GAYDVLGIDW TIEPSVAREM VADRVSLQGN
310 320 330 340 350 360
LDPCVLYCGD QVIRDQTQKM LQSFGTTKRL IANLGHGMHP THPIEGPESY VKAVHELSKQ
MINK