Q51947

PR
Gene name
nahE
Protein name
Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase
Names
THBPA hydratase-aldolase, 2'-hydroxybenzalpyruvate aldolase
Species
Pseudomonas putida (Arthrobacter siderocapsulatus)
KEGG Pathway
ag:AAA66357
EC number
4.1.2.45: Aldehyde-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q51947

Entry ID Method Resolution Chain Position Source
6DAO X-ray 194 A A/B 1-331 PDB
AF-Q51947-F1 Predicted AlphaFoldDB

No variants for Q51947

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q51947

No associated diseases with Q51947

No regional properties for Q51947

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q51947

Functions

Description
EC Number 4.1.2.45 Aldehyde-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
aldehyde-lyase activity Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.
trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde).

1 GO annotations of biological process

Name Definition
naphthalene catabolic process The chemical reactions and pathways resulting in the breakdown of naphthalene.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLNKVIKTTR LTAEDINGAW TIMPTPSTPD ASDWRSTNTV DLDETARIVE ELIAAGVNGI
70 80 90 100 110 120
LSMGTFGECA TLTWEEKRDY VSTVVETIRG RVPYFCGTTA LNTREVIRQT RELIDIGANG
130 140 150 160 170 180
TMLGVPMWVK MDLPTAVQFY RDVAGAVPEA AIAIYANPEA FKFDFPRPFW AEMSKIPQVV
190 200 210 220 230 240
TAKYLGIGML DLDLKLAPNI RFLPHEDDYY AAARINPERI TAFWSSGAMC GPATAIMLRD
250 260 270 280 290 300
EVERAKSTGD WIKAKAISDD MRAADSTLFP RGDFSEFSKY NIGLEKARMD AAGWLKAGPC
310 320 330
RPPYNLVPED YLVGAQKSGK AWAALHAKYS K