Q50I20

PR
Gene name
mcsA
Protein name
2-methylcitrate synthase, mitochondrial
Names
Methylcitrate synthase, (2S,3S)-2-methylcitrate synthase, Citrate synthase 1
Species
Neosartorya fumigata (Aspergillus fumigatus)
KEGG Pathway
EC number
2.3.3.5: Acyl groups converted into alkyl groups on transfer
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q50I20

Entry ID Method Resolution Chain Position Source
5UQO X-ray 250 A A/B 29-465 PDB
5UQQ X-ray 230 A A/B/C/D/E/F 29-465 PDB
5UQR X-ray 175 A A/B 29-465 PDB
5UQU X-ray 170 A A/B 29-465 PDB
6BOP X-ray 271 A A/B/C/D 29-465 PDB
AF-Q50I20-F1 Predicted AlphaFoldDB

No variants for Q50I20

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q50I20

No associated diseases with Q50I20

1 regional properties for Q50I20

Type Name Position InterPro Accession
active_site Citrate synthase active site 348 - 360 IPR019810

Functions

Description
EC Number 2.3.3.5 Acyl groups converted into alkyl groups on transfer
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

2 GO annotations of molecular function

Name Definition
2-methylcitrate synthase activity Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+).
citrate synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

1 GO annotations of biological process

Name Definition
propionate catabolic process The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAMTMRSTRH ASKLAQTARL ALTNSRRYST AEPDLKTALK AVIPAKRELF KQVKERSDEV
70 80 90 100 110 120
IGEVKVANVI GGMRGLKSML WEGSVLDPEE GIRFHGKTIK DCQKELPKGT SGTEMLPEAM
130 140 150 160 170 180
FWLLLTGQVP STNQVRAFSR ELAEQSHLPQ HILDLIKSFP RSMHPMTQLS IAVAALNTES
190 200 210 220 230 240
KFAKAYEKGL SKADYWEPTF DDSISLLAKI PRVAALVFRP DEVDQVGTQA LDASQDWSYN
250 260 270 280 290 300
FAELLGKGGK ENQDFHDLLR LYLALHGDHE GGNVSAHATH LVGSALSDPF LSYSAGLLGL
310 320 330 340 350 360
AGPLHGLAAQ EVLRWILAMQ DKIGTKFTDD DVRNYLWDTL KSGRVVPGYG HGVLRKPDPR
370 380 390 400 410 420
FQALMDFAAT RPDVLANPVF QLVKKNSEIA PAVLTEHGKT KNPHPNVDAA SGVLFYHYGF
430 440 450 460
QQPLYYTVTF GVSRALGPLV QLIWDRALGL PIERPKSINL LGLKK