AiPD: Autoinhibited Protein Database

Q504U0

Gene name	C4orf46 (RCDG1)
Protein name	Renal cancer differentiation gene 1 protein
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:201725
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-72 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q504U0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q504U0-F1	Predicted				AlphaFoldDB

101 variants for Q504U0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA108841634 rs575518153	2	A>G		No	ClinGen 1000Genomes TOPMed gnomAD
rs575518153 CA358572967	2	A>V		No	ClinGen 1000Genomes TOPMed gnomAD
rs771997932 CA3122233	3	D>E		No	ClinGen ExAC gnomAD
rs1272115230 CA358572956	4	P>L		No	ClinGen gnomAD
CA3122232 rs376877943	4	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs773359219 CA3122231	6	E>K		No	ClinGen ExAC gnomAD
CA358572919 rs1213853219	9	V>A		No	ClinGen gnomAD
rs1371638862 CA358572912	10	S>F		No	ClinGen gnomAD
rs748375809 CA3122229	11	S>L		No	ClinGen ExAC TOPMed gnomAD
CA108841614 rs926767530	14	P>L		No	ClinGen TOPMed gnomAD
CA108841609 rs926767530	14	P>R		No	ClinGen TOPMed gnomAD
CA358572890 rs1392603455	14	P>S		No	ClinGen gnomAD
CA358572873 rs1426922881	15	P>L		No	ClinGen TOPMed gnomAD
rs867000557 CA108841602	17	P>A		No	ClinGen TOPMed gnomAD
rs867000557 CA358572861	17	P>S		No	ClinGen TOPMed gnomAD
rs867000557 CA358572862	17	P>T		No	ClinGen TOPMed gnomAD
CA108841591 rs890415256	18	S>A		No	ClinGen TOPMed
rs1168955625 CA358572848	18	S>F		No	ClinGen gnomAD
rs755273406 CA3122227	21	S>F		No	ClinGen ExAC gnomAD
rs1422720817 CA358572777	24	D>H		No	ClinGen Ensembl
CA358572757 rs1252018754	25	A>D		No	ClinGen gnomAD
CA3122224 rs758832408	27	A>E		No	ClinGen ExAC gnomAD
rs145167320 CA358572741	27	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3122225 rs145167320	27	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	28	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1217265882 CA358572714	29	S>F		No	ClinGen TOPMed gnomAD
CA358572703 rs1203194299	30	S>F		No	ClinGen TOPMed gnomAD
CA3122222 rs750945797	31	P>L		No	ClinGen ExAC TOPMed gnomAD
CA358572698 rs1348561367	31	P>T		No	ClinGen gnomAD
rs753459998 CA3122220	33	G>D		No	ClinGen ExAC TOPMed gnomAD
CA358572679 rs1300857693	33	G>R		No	ClinGen gnomAD
rs753459998 CA3122219	33	G>V		No	ClinGen ExAC TOPMed gnomAD
CA3122218 rs141418697	34	P>A		No	ClinGen ESP ExAC gnomAD
rs141418697 CA358572669	34	P>S		No	ClinGen ESP ExAC gnomAD
rs1431310877 CA358572642	36	S>N		No	ClinGen TOPMed
rs146620946 CA3122215 CA108841533	37	L>F		No	ClinGen TOPMed gnomAD
CA3122214 rs142913539	38	G>C		No	ClinGen ExAC TOPMed gnomAD
CA108841494 rs148543446	39	W>R		No	ClinGen ESP
rs866237356 CA108841489	40	P>L		No	ClinGen Ensembl
CA108841482 rs140932563 COSM106372	42	P>S	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1376629005 CA358572573	43	S>T		No	ClinGen gnomAD
rs373406193 CA3122212 CA3122213	44	R>S		No	ClinGen ESP ExAC gnomAD
rs922235644 CA108841475	44	R>T		No	ClinGen Ensembl
rs145770834 CA108841468	45	S>I		No	ClinGen ESP TOPMed gnomAD
CA108841474 rs1038393624	45	S>R		No	ClinGen TOPMed
rs149785447 CA3122210	46	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs149785447 CA3122209	46	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs776593810 CA3122208	47	G>C		No	ClinGen ExAC TOPMed gnomAD
CA358572526 rs1303403286	47	G>D		No	ClinGen TOPMed
CA358572535 rs776593810	47	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1247955351 CA358572522	48	P>A		No	ClinGen gnomAD
CA358572505 rs369968557	49	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs369968557 CA108841439	49	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs369968557 CA3122207	49	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs747196215 CA3122206	51	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA358572468 rs1580385420	52	Q>P		No	ClinGen Ensembl
CA3122203 rs746373666	55	E>G		No	ClinGen ExAC gnomAD
rs140720883 CA3122204	55	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs750487027 CA3122202	56	V>L		No	ClinGen ExAC TOPMed gnomAD
CA108841423 rs989473296	57	E>D		No	ClinGen TOPMed
CA108841418 rs934321799	58	L>Q		No	ClinGen TOPMed gnomAD
rs1305087324 CA358572383	59	Q>H		No	ClinGen TOPMed gnomAD
CA3122200 rs753342205	61	G>E		No	ClinGen ExAC TOPMed gnomAD
CA358572352 rs1315359130	62	D>N		No	ClinGen gnomAD
CA3122166 rs764234322	64	A>G		No	ClinGen ExAC TOPMed gnomAD
rs764234322 CA3122165	64	A>V		No	ClinGen ExAC TOPMed gnomAD
CA358572079 rs1211934828	65	F>I		No	ClinGen gnomAD
rs1271299253 CA358572020	69	K>*		No	ClinGen gnomAD
CA358572016 rs1230176358	69	K>R		No	ClinGen gnomAD
rs759787177 CA3122161	71	L>F		No	ClinGen ExAC TOPMed gnomAD
CA358571996 rs759787177	71	L>I		No	ClinGen ExAC TOPMed gnomAD
CA108839702 rs761268688	71	L>P		No	ClinGen TOPMed
CA358571963 rs1442064769	73	A>D		No	ClinGen gnomAD
rs1396513721 CA358571905	78	S>L		No	ClinGen gnomAD
TCGA novel	79	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1002527185 CA108839684	80	Q>E		No	ClinGen TOPMed
rs749789362 CA3122158 COSM1198858	83	E>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs778183157 CA3122157	85	A>D		No	ClinGen ExAC gnomAD
rs1331413334 CA358571824	85	A>P		No	ClinGen TOPMed
rs747561747 CA3122155	87	K>T		No	ClinGen ExAC TOPMed gnomAD
rs780878022 CA3122154	88	C>G		No	ClinGen ExAC gnomAD
rs906840277 CA108839634	88	C>Y		No	ClinGen TOPMed gnomAD
CA108839631 rs1022643681	89	T>A		No	ClinGen gnomAD
CA108839628 rs796351756	89	T>K		No	ClinGen Ensembl
CA108839626 rs560001533	90	E>G		No	ClinGen 1000Genomes
CA108839627 rs796907635	90	E>K		No	ClinGen Ensembl
CA3122150 rs145987500	93	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145987500 CA3122151	93	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3122149 rs779978054	93	R>L		No	ClinGen ExAC gnomAD
COSM1428299 CA3122147 rs765140061 CA3122146	98	W>R	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA358571639 rs1335972990	99	R>Q		No	ClinGen gnomAD
CA358571641 COSM1052669 rs1435398716	99	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs947377817 CA108839595	101	L>V		No	ClinGen TOPMed
TCGA novel	104	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs141266470 CA108839591	105	G>A		No	ClinGen ESP TOPMed gnomAD
rs752735762 CA3122144	110	K>R		No	ClinGen ExAC gnomAD
CA3122142 rs759697233	111	P>R		No	ClinGen ExAC gnomAD
CA358571519 rs1392959367	113	D>N		No	ClinGen gnomAD
CA358571504 rs1477855958	114	D>C		No	ClinGen gnomAD
rs1171773479 CA358571510	114	D>R		No	ClinGen gnomAD
rs1481695026 CA358571508	114	D>S		No	ClinGen TOPMed

No associated diseases with Q504U0

2 regional properties for Q504U0

Type	Name	Position	InterPro Accession
domain	ABC1 atypical kinase-like domain	93 - 342	IPR004147
domain	UbiB domain, bacteria	92 - 343	IPR045308

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0II83		Uncharacterized protein C4orf46 homolog	Bos taurus (Bovine)	PR

10	20	30	40	50	60
MADPEELQVS	SPPPPPPSSP	SSSDASAASS	PGGPVSLGWP	VPSRSSGPTV	DQLEEVELQI
70	80	90	100	110
GDAAFSLTKL	LEATSAVSAQ	VEELAFKCTE	NARFLKTWRD	LLKEGYDSLK	PDD