Q500W7
Gene name |
PIGM (PNT1, At5g22130, T6G21.34) |
Protein name |
GPI mannosyltransferase 1 |
Names |
GPI mannosyltransferase I, GPI-MT-I, Phosphatidylinositol-glycan biosynthesis class M protein, PIG-M, Protein PEANUT 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G22130 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q500W7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q500W7-F1 | Predicted | AlphaFoldDB |
49 variants for Q500W7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00637319 | 2 | S>F | No | 1000Genomes | |
| tmp_5_7339821_T_C | 4 | E>G | No | 1000Genomes | |
| ENSVATH00637318 | 13 | S>P | No | 1000Genomes | |
| tmp_5_7339591_T_G | 17 | K>T | No | 1000Genomes | |
| ENSVATH10912231 | 30 | V>M | No | 1000Genomes | |
| ENSVATH10912230 | 34 | V>I | No | 1000Genomes | |
| tmp_5_7339504_C_T | 46 | R>Q | No | 1000Genomes | |
| ENSVATH07009659 | 80 | L>F | No | 1000Genomes | |
| ENSVATH07009658 | 92 | R>Q | No | 1000Genomes | |
| ENSVATH00637312 | 94 | W>L | No | 1000Genomes | |
| tmp_5_7339340_C_T | 101 | A>T | No | 1000Genomes | |
| ENSVATH10912227 | 112 | K>N | No | 1000Genomes | |
| tmp_5_7339100_G_T | 127 | S>Y | No | 1000Genomes | |
| ENSVATH00637306 | 159 | L>I | No | 1000Genomes | |
| tmp_5_7338444_G_T | 175 | L>I | No | 1000Genomes | |
| ENSVATH00637293 | 188 | L>S | No | 1000Genomes | |
| ENSVATH00637292 | 190 | I>T | No | 1000Genomes | |
| ENSVATH00637291 | 196 | T>A | No | 1000Genomes | |
| tmp_5_7338353_G_A | 205 | P>L | No | 1000Genomes | |
| ENSVATH00637290 | 206 | A>T | No | 1000Genomes | |
| tmp_5_7338344_A_G | 208 | L>S | No | 1000Genomes | |
| ENSVATH00637289 | 208 | L>V | No | 1000Genomes | |
| ENSVATH00637288 | 222 | M>T | No | 1000Genomes | |
| ENSVATH07009651 | 228 | L>F | No | 1000Genomes | |
| tmp_5_7338273_A_T | 232 | L>M | No | 1000Genomes | |
| tmp_5_7338267_T_A | 234 | T>S | No | 1000Genomes | |
| tmp_5_7338261_T_C | 236 | K>E | No | 1000Genomes | |
| tmp_5_7338232_C_T | 245 | M>I | No | 1000Genomes | |
| ENSVATH03091577 | 262 | F>Y | No | 1000Genomes | |
| tmp_5_7338089_T_C | 293 | H>R | No | 1000Genomes | |
| ENSVATH03091576 | 342 | T>A | No | 1000Genomes | |
| ENSVATH00637282 | 367 | H>L | No | 1000Genomes | |
| ENSVATH03091565 | 367 | H>Q | No | 1000Genomes | |
| ENSVATH00637282 | 367 | H>R | No | 1000Genomes | |
| ENSVATH03091563 | 380 | M>I | No | 1000Genomes | |
| ENSVATH03091564 | 380 | M>L | No | 1000Genomes | |
| tmp_5_7337671_A_C | 390 | L>V | No | 1000Genomes | |
| ENSVATH00637280 | 398 | K>R | No | 1000Genomes | |
| ENSVATH00637278 | 405 | P>L | No | 1000Genomes | |
| ENSVATH00637278 | 405 | P>Q | No | 1000Genomes | |
| ENSVATH00637277 | 408 | I>F | No | 1000Genomes | |
| ENSVATH07009648 | 411 | L>W | No | 1000Genomes | |
| tmp_5_7337584_A_C | 419 | F>V | No | 1000Genomes | |
| tmp_5_7337548_A_T | 431 | S>T | No | 1000Genomes | |
| ENSVATH07009646 | 438 | E>K | No | 1000Genomes | |
| ENSVATH03091557 | 444 | N>K | No | 1000Genomes | |
| ENSVATH08420897 | 449 | E>D | No | 1000Genomes | |
| ENSVATH08420899 | 449 | E>Q | No | 1000Genomes | |
| ENSVATH08420898 | 449 | E>V | No | 1000Genomes |
No associated diseases with Q500W7
No regional properties for Q500W7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q500W7 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| glycosylphosphatidylinositol-mannosyltransferase I complex | A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-1,4-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage. |
| glycolipid mannosyltransferase activity | Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage. |
| mannosyltransferase activity | Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| GPI anchor biosynthetic process | The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRESENTDD | EPSKWMKFRS | LLVFSMLLRV | FLIVYGEWQD | AHMEVRYTDV | DYIVFSDAAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LMASGESPYK | RTTYRYSPLL | ALLLTPNSFF | HRSWGKFLFS | ASDLLVGWFI | HKILKQRKVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKICTYSVMV | WLFNPFTFTI | GTRGNCEPIV | CAMILWIILC | LMQGNLLQAA | FWYGLVVHFR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VYPIIYALPI | ILVLDTQVFR | SGQKPALLYW | NTGQAKTPAS | NMERKTFLFN | LLTTLKSLFS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RERIMFALIS | GGVFLACNAV | SFYFYGQEFL | HEALLYHLTR | TDPRHNFSIY | FYHIYLHYER |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QFSAVEKLIS | FLPQFTVQFA | LVFCFSQDLV | FCIFLQTVAF | VTFNKVITAQ | YFVWFYCLLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LILPWSHMKL | KWEGLLCIIM | WIGAQTHWLL | WGYMLEFKGV | NVFLPLWIAS | LLFLAANTFV |
| 430 | 440 | ||||
| LVRIIQRHRF | SPLFRRYESS | SSSNNVTKED |