AiPD: Autoinhibited Protein Database

Gene name	TKPR1 (DRL1, At4g35420, F23E12.20)
Protein name	Tetraketide alpha-pyrone reductase 1
Names	Protein DIHYDROFLAVONOL 4-REDUCTASE-LIKE 1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G35420
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

55-124 (Predicted disordered autoinhibitory region) PR

55-124 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q500U8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_4_16835607_T_C	2	D>G	No	1000Genomes
ENSVATH12409240	17	L>S	No	1000Genomes
tmp_4_16835515_T_C	33	I>V	No	1000Genomes
tmp_4_16835397_A_C	45	L>R	No	1000Genomes
tmp_4_16835256_G_A	92	T>I	No	1000Genomes
ENSVATH06829253	105	E>K	No	1000Genomes
tmp_4_16835104_C_T	110	V>I	No	1000Genomes
ENSVATH06829251	116	K>E	No	1000Genomes
tmp_4_16835026_C_T	136	D>N	No	1000Genomes
ENSVATH02960841	141	K>Q	No	1000Genomes
ENSVATH02960840	145	D>N	No	1000Genomes
tmp_4_16834646_C_T	208	V>I	No	1000Genomes
tmp_4_16834640_C_T	210	G>R	No	1000Genomes
ENSVATH00553617	213	K>N	No	1000Genomes
tmp_4_16834450_C_G	239	V>L	No	1000Genomes
ENSVATH00553612	281	K>I	No	1000Genomes
ENSVATH00553612	281	K>T	No	1000Genomes
tmp_4_16834215_T_A	286	H>L	No	1000Genomes
ENSVATH12409202	312	I>L	No	1000Genomes
tmp_4_16834127_T_G	315	L>F	No	1000Genomes
tmp_4_16834123_C_T	317	E>K	No	1000Genomes
tmp_4_16834113_T_G	320	Y>S	No	1000Genomes
tmp_4_16834107_G_C	322	S>C	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	NAD-dependent epimerase/dehydratase	8 - 245	IPR001509

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Endoplasmic reticulum	According to PubMed:21193572, TKPR1 is associated with the endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

Name	Definition
pollen development	The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
pollen exine formation	The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine.
seed development	The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves.
sporopollenin biosynthetic process	The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins