Q4ZLZ9

PR
Gene name
ligB
Protein name
DNA ligase B
Names
Polydeoxyribonucleotide synthase [NAD(+)] B
Species
Pseudomonas syringae pv syringae (strain B728a)
KEGG Pathway
psb:Psyr_4796
EC number
6.5.1.2: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-129 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4ZLZ9

Entry ID Method Resolution Chain Position Source
AF-Q4ZLZ9-F1 Predicted AlphaFoldDB

No variants for Q4ZLZ9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4ZLZ9

No associated diseases with Q4ZLZ9

4 regional properties for Q4ZLZ9

Type Name Position InterPro Accession
domain NAD-dependent DNA ligase, OB-fold 316 - 390 IPR004150
domain NAD-dependent DNA ligase, adenylation 32 - 310 IPR013839
domain NAD-dependent DNA ligase, N-terminal 32 - 430 IPR013840
conserved_site NAD-dependent DNA ligase, conserved site 325 - 340 IPR033136

Functions

Description
EC Number 6.5.1.2 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLPTFRLMTC AIVFVLPGLG HASQCPDWPA AKARSEVTAL QQQIAEWDDS YHRQGISQIA
70 80 90 100 110 120
DELYDQARQK LNLWRSCFAV STPESDPLKT AVGPLPHPVP HTGVNKLADE GSVKGWLKGR
130 140 150 160 170 180
NDLWIQPKVD GVAVTLVYEK GRLVQAISRG DGRKGQDWTS QARLIKAIAQ QLPQAESTIL
190 200 210 220 230 240
QGELYWRLDD HIQAASGSVN ARSKVAGLLA RQTISPQQAD AIGLFVWDWP NGPADMAQRL
250 260 270 280 290 300
AGLQAMGFED SAAYTHPLEN YVQAARWREH WYRNPLPFAT DGVILRQGQR PPAQRWQASA
310 320 330 340 350 360
PYWIAAWKHP YAQALAEVRK VNFKIGRSGR ITPVLELTPV RLDDRTVSRI STGSLQRWQT
370 380 390 400 410 420
LDIRPGDQIA VSLAGLTIPR LDGVVSRAAE RADMIIPRAD DFHELSCWQA TPGCESQFRA
430 440 450 460 470 480
RLAWLSGKKG LALPGVGPGT WNTLIDNGQI MGLLDWMTLN HAELVNIPGF AERSSAKLLD
490 500 510 520 530 540
SLQTARERPF QTWLKAIGLP PTGGARLPDN WHELAGRSVE QWQAEPGIGP GRAARLRAFF
550 560
QDPQVQALSQ QLQAQSISGF K