AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

249-319 (Predicted disordered autoinhibitory region) PR

249-319 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q4ZJM7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs251273182	11	L>F	No	EVA
rs3388630228	19	V>M	No	EVA
rs238348388	20	A>G	No	EVA
rs3393177113	26	T>K	No	EVA
rs3388632217	30	K>R	No	EVA
rs3388632115	51	F>L	No	EVA
rs3388638066	83	G>A	No	EVA
rs3388635165	88	A>G	No	EVA
rs3388635176	89	T>I	No	EVA
rs248907808	91	R>H	No	EVA
rs260606842	140	S>I	No	EVA
rs3393196087	168	Q>K	No	EVA
rs3388624110	206	S>A	No	EVA
rs239358369	249	R>Q	No	EVA
rs3388635125	292	G>C	No	EVA
rs3388632271	345	V>I	No	EVA
rs3388632182	403	G>A	No	EVA
rs36663775	411	V>M	No	EVA
rs3413022446	464	D>H	No	EVA
rs37389056	479	S>R	No	EVA

Type	Name	Position	InterPro Accession
domain	C1q domain	341 - 478	IPR001073
repeat	Collagen triple helix repeat	118 - 175	IPR008160-1
repeat	Collagen triple helix repeat	244 - 341	IPR008160-2

		Description
EC Number
Subcellular Localization	Secreted, extracellular space, extracellular matrix	Localized in both the surrounding otoconial matrix and otoconia
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
collagen type IV trimer	A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.
extracellular matrix	A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
extracellular matrix structural constituent	The action of a molecule that contributes to the structural integrity of the extracellular matrix.

Name	Definition
collagen-activated tyrosine kinase receptor signaling pathway	The series of molecular signals initiated by collagen binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
extracellular matrix organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
otolith mineralization	The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear.
protein homooligomerization	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins