Q4X0C2

PR
Gene name
dbp9 (AFUA_2G13980)
Protein name
ATP-dependent RNA helicase dbp9
Names
Species
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KEGG Pathway
afm:AFUA_2G13980
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-156 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4X0C2

Entry ID Method Resolution Chain Position Source
AF-Q4X0C2-F1 Predicted AlphaFoldDB

No variants for Q4X0C2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4X0C2

No associated diseases with Q4X0C2

4 regional properties for Q4X0C2

Type Name Position InterPro Accession
domain Helicase, C-terminal 277 - 514 IPR001650
domain DEAD/DEAH box helicase domain 81 - 254 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 76 - 281 IPR014001
domain RNA helicase, DEAD-box type, Q motif 57 - 85 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
DNA/RNA helicase activity Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRKTFQPVVS YNQASFKGPS QRLLELCVVN MKRKLDANDV PSTEVEEEKN TKDADNTDFE
70 80 90 100 110 120
SLNLDPRLRQ ALIKEQFTKP TPVQSKAIPL ALEGKDILAR AKTGSGKTAA YVLPILQTIL
130 140 150 160 170 180
QKKAADPSLK ATTGLILVPT RELAEQVQSV IIKFSAFCGK DVRSVNLTQK VSDAVQRTML
190 200 210 220 230 240
ADYPDLIVST PARVIANLGT SALSLENLTH LVIDEADLVL SYGYDEDINA LAKAIPRGVQ
250 260 270 280 290 300
TFLMSATLTS EVDTLKGLFC RSPVILKLED KEDEGAGISQ FVVRCAEDEK FLLTYVIFKL
310 320 330 340 350 360
QLIKGKVIIF VGDIDRCYRL KLFLEQFGIK SCVLNSELPI NSRIHVVQEF NKGVYDIIIA
370 380 390 400 410 420
ADEQEVMGLR TSSKKSKEAT DGDDEAKDKM GSSEDEDNEP EQSGKSARPE KRRKTSGKAK
430 440 450 460 470 480
DYGISRGIDF QNVACVLNFD LPTTSKSYTH RIGRTGRAGK AGMALSFVVP ADKFGKHKPT
490 500 510 520 530 540
SFPTAKHDES VLAKIVKKQA KLGHEVKPYH FEMKQVDAFR YRMTDALRAV TRLAIQEARA
550 560 570 580 590 600
REIRQELVKS EKLKRHFEEN PEELKQLRHD GELRAARIQP HLKHIPDYLM PSKGRKGISS
610 620 630 640
EDVGFVGFRK SGDNRIRKAR EKNRGKGKGR KPSGVRKVDP LKTFNRGRK