Q4WZP2

PR
Gene name
csn5 (AFUA_2G16250)
Protein name
COP9 signalosome complex subunit 5
Names
Species
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KEGG Pathway
afm:AFUA_2G16250
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

235-330 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4WZP2

Entry ID Method Resolution Chain Position Source
AF-Q4WZP2-F1 Predicted AlphaFoldDB

No variants for Q4WZP2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4WZP2

No associated diseases with Q4WZP2

3 regional properties for Q4WZP2

Type Name Position InterPro Accession
domain JAB1/MPN/MOV34 metalloenzyme domain 48 - 186 IPR000555
domain MPN domain 51 - 187 IPR037518
domain Cop9 signalosome subunit 5 C-terminal domain 248 - 323 IPR040961

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
deNEDDylase activity An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

1 GO annotations of biological process

Name Definition
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQAAQQSWEL ENTISLIDPQ RDALYRYDEE THKALSAARP WAKDPHYFKS IRISAVALIK
70 80 90 100 110 120
MTMHARSGGS LEVMGLMQGY ILPETFVVTD AFRLPVEGTE TRVNAQEEAN EYMVSYLQSC
130 140 150 160 170 180
RDAGRMENAV GWYHSHPGYG CWLSGIDVTT QDMQQLGGPF VAVVIDPERT ISAGKVDIGA
190 200 210 220 230 240
FRTFPKDYTP PKEGNEDEDY QTIPLSKAED FGAYAHQYYS LEVSFFKSSL DTELLSQLWN
250 260 270 280 290 300
KYWVATLSQS PLFTTRDYGS RQMMDLSQKV RRAARGIESS GSRGGATTPK DQQLEKIVRD
310 320 330
GQRIVSEEVK GLLAAEVKMK LFQGIGEGTQ TGAS