Q4WZ67

PR
Gene name
easL
Protein name
Fumigaclavine A dimethylallyltransferase easL
Names
Ergot alkaloid synthesis protein L, Tryptophan aminopeptidase
Species
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KEGG Pathway
afm:AFUA_2G17990
EC number
2.5.1.100: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4WZ67

Entry ID Method Resolution Chain Position Source
AF-Q4WZ67-F1 Predicted AlphaFoldDB

No variants for Q4WZ67

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4WZ67

No associated diseases with Q4WZ67

No regional properties for Q4WZ67

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q4WZ67

Functions

Description
EC Number 2.5.1.100 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
dimethylallyltranstransferase activity Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).
protein homodimerization activity Binding to an identical protein to form a homodimer.
transferase activity, transferring alkyl or aryl (other than methyl) groups Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).

3 GO annotations of biological process

Name Definition
alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases).
ergot alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of an ergot alkaloid.
fumigaclavine C biosynthetic process The chemical reactions and pathways resulting in the formation of fumigaclavine C, a fungal ergot alkaloid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKTDAQGRH PQETATHAAT TDEEVQDQWR APFEVLSRTL VFQHEDHRLW WERAASKLAT
70 80 90 100 110 120
YLRLAKYSVG SQYQHLLMFY SVYAPNLGPW PNDKRDNVHW VCGICPGGEN LEISMNYQQG
130 140 150 160 170 180
AKCTVRIAAE TITPAAGTDK DPFNLTAEKK MIEDLKALQP NLNFTWFNHF QREVLVPEEV
190 200 210 220 230 240
ALNNDEIISK VPFKNQRLHG LDLSEGAFML KSYFMPAIRS AITGVENTQI MFESIRKLNL
250 260 270 280 290 300
KNANFISALS TLEDWMVPTN GRFMEYWDGI SYDAVDACKA RIKIYTGIRM KSIEHARDVW
310 320 330 340 350 360
TLGGRLQGED IEKGFDLVAR LWRRLMDEEP STCEMKYWMQ WVWELRTDVP FPVPKLYFSV
370 380 390 400 410 420
AAAEDHYVSD TVVEILDYLG WDDLVQTHRA LMDEAWSLGQ TTKSYLAFSY ISVTFHSIKG
430
PYITTYGNPS GPRPVF