Q4WVD1

PR
Gene name
ppm2 (tyw4, AFUA_5G11670)
Protein name
tRNA wybutosine-synthesizing protein 4
Names
tRNA-yW synthesizing protein 4, Leucine carboxyl methyltransferase 2, tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
Species
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KEGG Pathway
afm:AFUA_5G11670
EC number
2.1.1.290: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4WVD1

Entry ID Method Resolution Chain Position Source
AF-Q4WVD1-F1 Predicted AlphaFoldDB

No variants for Q4WVD1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4WVD1

No associated diseases with Q4WVD1

2 regional properties for Q4WVD1

Type Name Position InterPro Accession
domain JmjC domain 814 - 1003 IPR003347
domain Cupin-like domain 8 737 - 989 IPR041667

Functions

Description
EC Number 2.1.1.290 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
tRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.

2 GO annotations of biological process

Name Definition
tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
wybutosine biosynthetic process The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazopurine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGAAKKPAAA GVSTKAEREA DLVMETNNSS IVSKRSVELL YYPKPHFFRY FVKRPPRRSP
70 80 90 100 110 120
LINRGYWLRM HAMAESVRQF MKQPSDKPKF VLNLGCGFDP LPFILLSTDK SLCSTTRFVD
130 140 150 160 170 180
IDYEKLMVNK KTAIRRTDEI TRLLENVEFL SDESPIQIRS EQYLAIGCDL KNLKKLDDVL
190 200 210 220 230 240
KTELLPSDCS ILFLAEVSLT YMDVKSANAV LAWASKLNND SQFCILEQFF PDGPNHPFAS
250 260 270 280 290 300
TMMKHFNKLG APLYSIHEYR SLSEQEQRFR NAGWAHAQAR SLWDLWSDNE FVGSSLRAWL
310 320 330 340 350 360
DTVEPFDEWE EFALFASHYF LLVASTKPQT MVQELQKTPA LTTEPDISSQ YVLLAGNNPR
370 380 390 400 410 420
GGQRRFGALI PDSENSMGHH SGLGRQTRDV STDLYSTCKG MTTPQLPFPP REVSARMCHT
430 440 450 460 470 480
VTSLRGGDCL LVGGRASPAN AFQDCWLRQG KQWQSTKSLP APRFRHSAVK ITLETDSESV
490 500 510 520 530 540
LVYGGKSSDG SIFDTWLLWQ THSNGWQEVE IQGARPPARF GACLESINQT TGVLFGGIGS
550 560 570 580 590 600
DGIIIEDFWI WKIRHRSDGT VFLELTDHTE HLQQTPLSQY IYRFGSTVTR TSRGLVIVGG
610 620 630 640 650 660
IIPRQIVPYE CEIMLLDVGE LLEYVENESS WGHRILSAIG LGGILQGARP LLVGHVACAI
670 680 690 700 710 720
DPDQVLILGG GAVCFSFGTF WTEGGWVLKP AGSTAQNNWT LVPEAMHTPE PVASPKTPQI
730 740 750 760 770 780
STALKLSSIR RIRVDTSEQF QQILADGKPV IIEGSDIGPC TELWTKEYLT DVVGSDRKVV
790 800 810 820 830 840
VHESQSENMN FQAKNFSYVT KAFGDFLDEV HAGGRQYLRS ISAELPSKLP ANLAADFPGL
850 860 870 880 890 900
KDDFKLPQAL SLVTENAHSS PLRISGPVTM WLHYDVSSNT KQEGWKLRVA DRYAQVMANV
910 920 930 940 950 960
LCQIRGERRL VLFPPADVQY LQVPPGASSS TIDIFQNIKD GSIVSIPHTS PQEAVLNSGD
970 980 990 1000 1010 1020
ILFIPPMWLH TASPTGGVSV AVNVFFRSLP KGYAAGRDVY GNRDLQAYEK ARIDIQKMVR
1030 1040
SFDGLPSDIS RFYLLRLAQE LKDNAGV