Q4WPG0

PR
Gene name
gpi10 (AFUA_4G09130)
Protein name
GPI mannosyltransferase 3
Names
GPI mannosyltransferase III, GPI-MT-III, Glycosylphosphatidylinositol-anchor biosynthesis protein 10
Species
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KEGG Pathway
afm:AFUA_4G09130
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4WPG0

Entry ID Method Resolution Chain Position Source
AF-Q4WPG0-F1 Predicted AlphaFoldDB

No variants for Q4WPG0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4WPG0

No associated diseases with Q4WPG0

3 regional properties for Q4WPG0

Type Name Position InterPro Accession
domain Guanylate kinase-like domain 12 - 191 IPR008144
domain Guanylate kinase/L-type calcium channel beta subunit 11 - 194 IPR008145
conserved_site Guanylate kinase, conserved site 46 - 63 IPR020590

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
alpha-1,2-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.
glutathione binding Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
glycolipid mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage.
mannosyltransferase activity Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

1 GO annotations of biological process

Name Definition
GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSSRRRKSF TSSSSSSSPS FHSPPPTSRL RPRSPPSSNT KTSPTSTTPL ATNILLSLIA
70 80 90 100 110 120
FRLVNAFTVR TFFQPDEFFQ SLEPAWQIAF GENQGAWITW EWRHQLRSSI HPLLFAAVYS
130 140 150 160 170 180
AADVVAQLLR LSLASRADLL VAAPKTAQAV IAGLGDFYTW KLARYVYGAR SYEAWATLAL
190 200 210 220 230 240
TVVSPWQWFC STRTLSNCLE TTITIVALYL WPWSWSFETP VRKKATRAAS RERAQRGPEG
250 260 270 280 290 300
SDSLQRLRQC LSLAAVACIL RPTNILIWMG LASVAWFRTS WDRRAILVRE VLLCGCAVLG
310 320 330 340 350 360
LSCVVDRLFY GSWTFPPLRF LYFNIAQSLA VFYGRNDWHY YVSQGFPLLL TTALPFALVG
370 380 390 400 410 420
LYRALAQVRT FGLGHLQSLV QAQLALICVI MPFVLSLVSH KEVRFIYPLL PSLHILSAPP
430 440 450 460 470 480
LVDYFLPAVI RSSRSYTPRR LTLIFLLLVN IVIALYTTIY HASGPSNILS YLRQQHELHA
490 500 510 520 530 540
PAAQTPSNLR PSVKDPSPHG ITAGFLMPCH STPWRSHLIY PTIHAWALTC EPPVDQTAAQ
550 560 570 580 590 600
KATYIDEADQ FYANPARFLR EHMAGGLRHI SRKPSYLSAQ PRPQHPSTTS TNDASHEWPD
610 620 630 640 650 660
YLIFFAQLEP TLQSLLRASS YAECYRTFNT AWHDDWRRKG DIVAWCLDPA EQQAWRSATR
670 680 690 700 710 720
QRDLENRERQ FDRIIESFRK EASGKRDGKL SPFRRWFSSS SSVAPSSSLS LSWPTSWRWP
730 740 750 760 770
WGQRKRTAWL GVQIPQWTRT RPSWTAWGGD WFGGWRQKKK TKKLLERDLW S