Q4WKH9
Gene name |
rvb2 (AFUA_1G02410) |
Protein name |
RuvB-like helicase 2 |
Names |
|
Species |
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
KEGG Pathway |
afm:AFUA_1G02410 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4WKH9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4WKH9-F1 | Predicted | AlphaFoldDB |
No variants for Q4WKH9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4WKH9 | |||||
No associated diseases with Q4WKH9
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| Ino80 complex | A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity. |
| NuA4 histone acetyltransferase complex | A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). |
| R2TP complex | A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others. |
| Swr1 complex | A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| box C/D snoRNP assembly | The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex. |
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| histone acetylation | The modification of a histone by the addition of an acetyl group. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVPISTVAE | TKELRGLNLI | AAHSHIRGLG | VDADSLQPRT | SSQGLVGQEK | ARKAAAVILQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MVKEGKIAGR | AVLIAGPPST | GKTAIAMGMA | QSLGSDVPFT | MLAASEIFSM | EMSKTEALTQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AFRKSIGVRI | KEESEIIEGE | VVEIQVDRSV | TGGNKQGKLT | IKTTDMETIY | DMGTKMIDSM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TKERVMAGDV | ISIDKSSGKI | TKLGRSYARS | RDYDAMGADT | KFVQCPEGEL | QVRKEIVHTV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLHEIDVINS | RTQGFLALFS | GDTGEIRSEV | RDQINTKVAE | WKEEGKAEII | PGVLFIDEVH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MLDIECFSYI | NRALEAELAP | IVIMASNRGQ | ARIRGTTYTS | PHGLPLDFLD | RVVIVSTQPY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SGDEIRQILA | IRAQEEEIDL | SPDALALLTK | IGQESNLRYA | SNIITTSHLL | SQKRKAKEVS |
| 430 | 440 | 450 | 460 | ||
| IDDVQRSYRL | FYDPARSVKF | VNAYEQRFIG | DQGAVNFSAP | ANGDAMEIS |