Q4WJW8

PR
Gene name
mcr1 (AFUA_1G04540)
Protein name
NADH-cytochrome b5 reductase 2
Names
Mitochondrial cytochrome b reductase
Species
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KEGG Pathway
afm:AFUA_1G04540
EC number
1.6.2.2: With a heme protein as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4WJW8

Entry ID Method Resolution Chain Position Source
AF-Q4WJW8-F1 Predicted AlphaFoldDB

No variants for Q4WJW8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4WJW8

No associated diseases with Q4WJW8

2 regional properties for Q4WJW8

Type Name Position InterPro Accession
domain Zinc finger, RING-type 53 - 100 IPR001841
domain Zinc finger, RING-CH-type 45 - 106 IPR011016

Functions

Description
EC Number 1.6.2.2 With a heme protein as acceptor
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.

1 GO annotations of molecular function

Name Definition
cytochrome-b5 reductase activity, acting on NAD(P)H Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).

1 GO annotations of biological process

Name Definition
ergosterol biosynthetic process The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFARQSLRVA QPLKQGFRKY STEAPSKGKS SLAPIYLGVG LIGLGVGLYR YNSASAEAPP
70 80 90 100 110 120
AERPKVFTGG DQGWVDLKLA QIENLSPNTK RLRFEFPDKE AVSGLHVASA LLTKFKPQGA
130 140 150 160 170 180
EKPVIRPYTP VSDEEQPGYL DLVVKVYPNG PMSEHLHSMN VDQRLEFKGP IPKYPWEANK
190 200 210 220 230 240
HKHICLIAGG TGITPMYQLA RKIFKDPEDQ TKVTLVFGNV REEDILLKKE LEELENTYPR
250 260 270 280 290 300
RFRAFYLLDH PPKEWTGGKG YITKELLKTV LPEPKEENIK IFVCGPPGMY KSISGPKVSP
310 320
TDQGELTGIL AELGYSKDQV FKF