Q4WI16

PR
Gene name
tim50 (AFUA_2G03420)
Protein name
Mitochondrial import inner membrane translocase subunit tim50
Names
Species
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KEGG Pathway
afm:AFUA_2G03420
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-210 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4WI16

Entry ID Method Resolution Chain Position Source
AF-Q4WI16-F1 Predicted AlphaFoldDB

No variants for Q4WI16

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4WI16

No associated diseases with Q4WI16

1 regional properties for Q4WI16

Type Name Position InterPro Accession
domain FCP1 homology domain 218 - 370 IPR004274

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
TIM23 mitochondrial import inner membrane translocase complex The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSAARPVSF PKSRWYAKSS KPKAPYKLPE SVKPPQSEQP SSTPKPEYSA EQTEFDTKAD
70 80 90 100 110 120
PAGNAAPEAS EATESKPQQP LPDLTQGIPS TLAAELEGRT KKSGQTSLNL TEDPSRFEDY
130 140 150 160 170 180
TDDGRGDIPK DGYVSSLDRR RARMANLMYA FFLLAGAGGV AYLGRNWETE EEAKAHPDIP
190 200 210 220 230 240
SGWSFSSWYN RMKARLSDIT SYYKDPAFPK LLPDEDPNLR QPYTLVLSLE DLLVHSEWSR
250 260 270 280 290 300
EHGWRIAKRP GVDYFLRYLN QYYELVLFTS VPSMMADQVL RKLDPYRIIR WPLFREATRY
310 320 330 340 350 360
KDGEYIKDLS YLNRDLSKVI LIDTKEEHAR LQPENAIILD KWLGDPKDKN LVALIPFLEY
370 380 390 400 410 420
IAGMGVEDVR PVLKSFEGTS IPVEFAKRER IMREKFEKEL EEERKRRPKR GVGSLASALG
430 440 450 460 470 480
LKSTRTLDGE QSPSEGLAQG KMLWDQIRER GQKNYEMIEK EIRENGEKWL AEMAAEEEKA
490 500
RQEQMKMMKG SFTSMFGAGK Q