Q4WH96

PR
Gene name
rgr1 (med14, AFUA_2G06180)
Protein name
Mediator of RNA polymerase II transcription subunit 14
Names
Mediator complex subunit 14
Species
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KEGG Pathway
afm:AFUA_2G06180
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4WH96

Entry ID Method Resolution Chain Position Source
AF-Q4WH96-F1 Predicted AlphaFoldDB

No variants for Q4WH96

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4WH96

No associated diseases with Q4WH96

No regional properties for Q4WH96

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q4WH96

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
core mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

1 GO annotations of molecular function

Name Definition
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPGVIMDNAT TGRPGHAPDT QTPSNGDNLR NGSFHINGAA KGDKDHDPDK ESYAGKPRID
70 80 90 100 110 120
GHRALPEIPH ITQGFFPFST LVNRSVQQCW NELSDLITEL AAIHVSPHSS VPLLPVNGKS
130 140 150 160 170 180
PGNQSPENVQ KKLRILDFAH AKRAEFIKLL VLSQWSRRAR DVSKLIDLQN FIRARHQAFV
190 200 210 220 230 240
DALQRVGEMK RDLVQAQVAN PDLQTALEIL SKGRLESLAD LGYKSSKLLT ARGALRRLHK
250 260 270 280 290 300
INRIISARLA LHDLIPHPFR TYRVHDGRVT FVVRGEFELD LSIGAESELS QFFFVDIRFL
310 320 330 340 350 360
YSPSSNIPKG RMSNEIDAKI NEKLRDSGLT GCFNFLHGLV LTNKIHILFK QAIELAKGLW
370 380 390 400 410 420
SETLRVELLH RTLVIQYWTL KPGPKSWIEI GVKSGNGDAD SQGLGVPCLG LRWMRDGQEV
430 440 450 460 470 480
NSRDIEFDPE DLSMECLLRS VIALHISYLL SSAYGILSEY SLFSSGTLSS HAILNVTEPG
490 500 510 520 530 540
ECQLSVQLTG SRHLRVSIEP MSGAVILSAT PGLLERFESD ASLDRSTIDD LVARVSRLRC
550 560 570 580 590 600
IAAIEELESN VRILGFETVS PKGLRNDIRK VFPANVLRFS LFWHPLWERN WVVAATSSIT
610 620 630 640 650 660
SDNWWVVRLR RSSEVATDFS VSDTSVPLCS GHSMSDTFLA TSHQTRSSSF PDLGYCLSGM
670 680 690 700 710 720
VAIYANVSYL SDLHSVEFHP PLCALKVESD LQIPDIFIRY QVSNLPRALQ LVLPAGLKRK
730 740 750 760 770 780
NLLKDTVRLA FHGIDRHKNS AIFVAYGNLV GPWTDLCTLI SKSDSSLVFK QGGSGFALRL
790 800 810 820 830 840
LAPAGRPVIV QLFKSLQTLE CTLSILDFLR QRRLTPQSLS LTHIAFAYGP GRDLSATIEM
850 860 870 880 890 900
GLSEVPSSAE LDPVRVLART DPLLCLTLGI RFKHPNPHRR VQGSLAAILN HASNEAGLDF
910 920 930 940 950 960
VTEVLSFTLP LMRALEQITS NASRQEPFRL QVIVRNAYTF LLHYTYQGFR FQLTTRQHSG
970 980 990 1000 1010 1020
QLTWVLRELS SPEAGPGHDQ FKARLRGTLY HSKGNGWKGL GNGVVADAEG VSNVIRALDG
1030 1040 1050 1060 1070 1080
CFTGAQHNTW LPRETKSEQD YSTQPAPENQ SQTGAPSQAG MANDTKMTAN FVNDKSLQRN
1090
PVVSNAADVI TID