Q4WCX7

PR
Gene name
AFUA_6G02780
Protein name
Acyl-protein thioesterase 1
Names
Palmitoyl-protein hydrolase
Species
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KEGG Pathway
afm:AFUA_6G02780
EC number
3.1.2.22: Thiolester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

199-241 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4WCX7

Entry ID Method Resolution Chain Position Source
AF-Q4WCX7-F1 Predicted AlphaFoldDB

No variants for Q4WCX7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4WCX7

No associated diseases with Q4WCX7

1 regional properties for Q4WCX7

Type Name Position InterPro Accession
domain Phospholipase/carboxylesterase/thioesterase 8 - 229 IPR003140

Functions

Description
EC Number 3.1.2.22 Thiolester hydrolases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond.
palmitoyl-(protein) hydrolase activity Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.

2 GO annotations of biological process

Name Definition
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
protein depalmitoylation The removal of palymitoyl groups from a lipoprotein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPPRAPYIV PALKKHTATV IMAHGLGDRM SLAQNWRRRG MFDEVAFIFP NAPMIPITVN
70 80 90 100 110 120
FGMTMPGWHD LTKLGRELDY ESAIRHQDEP GVLRSRDYFN TLIKEQIDKG IKPSRIVLGG
130 140 150 160 170 180
FSQGAAISVF TGITCKEKLG GVFGLSSYLV LSDKLKNYIP ENWPNKKTPF FLAHGLEDEI
190 200 210 220 230 240
VLFDFGDLSA KKMKEIGLED VTFKSYPNLG HSADPVEIED LARFLQKVIP PEDDGQASAG
L