Q4WC55
PR
Gene name |
myoA (AFUA_8G05660) |
Protein name |
Myosin-1 |
Names |
Class I unconventional myosin, Type I myosin |
Species |
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
KEGG Pathway |
afm:AFUA_8G05660 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4WC55
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4WC55-F1 | Predicted | AlphaFoldDB |
No variants for Q4WC55
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4WC55 | |||||
No associated diseases with Q4WC55
5 regional properties for Q4WC55
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 1076 - 1137 | IPR001452 |
| domain | Myosin head, motor domain | 45 - 731 | IPR001609 |
| domain | Class I myosin tail homology domain | 775 - 978 | IPR010926 |
| domain | Fungal myosin-I, SH3 domain | 1083 - 1134 | IPR035535 |
| domain | Class I myosin, motor domain | 65 - 717 | IPR036072 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cortical patch | An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae. |
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| cell tip | The region at the end of the longest axis of a cylindrical or elongated cell. |
| myosin complex | A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
| microfilament motor activity | A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| vesicle transport along actin filament | Movement of a vesicle along an actin filament, mediated by motor proteins. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGHSRRPAGG | EKKSRGFGRS | KAVADVGDGR | QTGGKPQVKK | ATFESTKKKE | IGVSDLTLLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KISNEAINDN | LKLRFEHDEI | YTYIGHVLVS | VNPFRDLGIY | TDNVLQSYRG | KNRLEVPPHV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FAVAESAYYN | MKSYKDNQCV | IISGESGAGK | TEAAKRIMQY | IASVSGGTDS | SIQHTKDMVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ATNPLLESFG | NAKTLRNNNS | SRFGKYLELE | FNTNGEPVGA | NITNYLLEKS | RVVGQITNER |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NFHIFYQFTK | AAPQKYRDLF | GIQQPQSYLY | TSRSKCFDVP | GVDDSAEFRD | TLNAMNVIGM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TEGEQDEVFR | MLAAILWIGN | VQFAEDDSGN | AVITDQSVVD | YVAYLLEVDA | AQVNKAFTIR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VMETARGGRR | GSVYEVPLNT | VQALAVRDAL | AKAIYFNLFD | WIVQRVNASL | TARGEVANSI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GILDIYGFEI | FEKNSFEQLC | INYVNEKLQQ | IFIQLTLKAE | QDEYAREQIQ | WTPIKYFDNK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VVCSLIEDKR | PPGVFAALND | ACATAHADSS | AADNTFVGRL | NFLSQNPNFE | NRQGQFIIKH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YAGDVSYAVA | GMTDKNKDQL | LKDLLNLVGT | SGNQFVHTLF | PEQVNQDDKR | RPPTASDKIK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ASANDLVATL | MKAQPSYIRT | IKPNDNKAPR | EYNVGNVLHQ | IKYLGLQENV | RIRRAGFAYR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QTFDKFVERF | YLLSPKTSYA | GDYTWTGDAE | SGARQILKDT | SIPAEEYQMG | ITKVFVKTPE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TLFALEAMRD | RYWHNMAIRI | QRAWRNYLRY | RTECAIRIQR | FWRRTTGGLE | FIKLRDQGHQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LLNGRKERRR | MSLLGSRRFL | GDYIGVGNKG | GPGEMVRNGA | GISGSEEILF | SCRGEVLVSK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FGRSSKPAPR | ILALTNRHVY | IIAQNLVNNQ | LVISSERTIP | IGAIKAVGAS | NLKDDWFSIV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VGSPQEPDPL | VNCVFKTEFF | THLNNALRGQ | LNLKIADHIE | YNKKPGKLAT | VKVVKDPAVA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RDDSYKSGTI | HTGPGEPANS | VSKPTPRPKQ | VSARPVTKGK | LLRPGGPGGG | PSKLAARPTP |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AAQPLPRATP | QPAEPQPAAR | AVPQPVAAVA | ASHTRTGSTA | SVRAPPPPPP | AAAPAPKKPT |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| AKVLYDFNSQ | QSNELSIKAG | EIVQIVSKEG | NGWWLCMNMT | TSAQGWTPEA | YLEEQVAPTP |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KPAPPPPPAA | PRSTPAPATN | GAAAAAKAKP | APPAPPAKRP | NMAARKAVPT | PPPAPRDSAV |
| 1210 | 1220 | 1230 | 1240 | ||
| SMNSHDSSGG | SGRGTPNSMS | NASLAGGLAE | ALRARQHAMQ | GKQDDDDDW |