AiPD: Autoinhibited Protein Database

Q4VXA5

Gene name	KHDC1
Protein name	KH homology domain-containing protein 1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:80759
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-105 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

27-105 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q4VXA5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q4VXA5-F1	Predicted				AlphaFoldDB

224 variants for Q4VXA5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1229798693 CA364698652	2	L>V		No	ClinGen gnomAD
rs1291795324 CA364698543	9	F>L		No	ClinGen TOPMed gnomAD
rs1414612160 CA364698535	9	F>S		No	ClinGen gnomAD
rs1291795324 CA364698541	9	F>V		No	ClinGen TOPMed gnomAD
rs928686184 CA140915203	10	R>*		No	ClinGen gnomAD
rs1562263204 CA364698517	10	R>L		No	ClinGen Ensembl
rs1452275421 CA364698505	11	V>A		No	ClinGen gnomAD
rs1344630209 CA364698481	13	F>L		No	ClinGen TOPMed gnomAD
CA364698479 rs1344630209	13	F>V		No	ClinGen TOPMed gnomAD
CA140915202 rs981481837	15	I>T		No	ClinGen TOPMed
rs1332436720 CA364698431	16	E>Q		No	ClinGen TOPMed
CA364698411 rs1215264684	17	T>A		No	ClinGen TOPMed
CA140915196 rs778488974	17	T>R		No	ClinGen TOPMed gnomAD
TCGA novel	18	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364698353 rs1175667283	21	Y>*		No	ClinGen TOPMed
CA3887691 rs16883573	21	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364698355 rs16883573	21	Y>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364698344 rs1186945372	23	V>I		No	ClinGen gnomAD
rs1184650914 CA364698319	26	F>L		No	ClinGen gnomAD
CA140915185 rs868770597	30	W>*		No	ClinGen TOPMed gnomAD
rs1260763132 CA364698287	31	P>S		No	ClinGen gnomAD
rs16883571 CA3887690	34	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA140915183 rs547364947	35	T>I		No	ClinGen gnomAD
rs547364947 CA364698259	35	T>N		No	ClinGen gnomAD
rs781408044 CA3887688	37	A>T		No	ClinGen ExAC
rs1001451392 CA140915162 CA364698219	42	G>R		No	ClinGen TOPMed gnomAD
CA364698206 rs1380980355	44	V>A		No	ClinGen gnomAD
CA364698208 rs768630898	44	V>L		No	ClinGen ExAC TOPMed gnomAD
rs768630898 CA3887687	44	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1374955417 CA364698179	48	L>F		No	ClinGen TOPMed
CA364698169 rs1392553471	49	W>*		No	ClinGen TOPMed gnomAD
CA140915159 rs868362643	51	R>H		No	ClinGen TOPMed gnomAD
CA364698155 rs868362643	51	R>L		No	ClinGen TOPMed gnomAD
rs957280686 CA140915158	53	N>S		No	ClinGen Ensembl
CA364698134 rs1168097103	55	E>Q		No	ClinGen gnomAD
CA364694181 rs1170347160	56	R>T		No	ClinGen gnomAD
rs890769600 CA140903477	57	N>I		No	ClinGen TOPMed
TCGA novel	57	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs971734882 CA140903452	59	R>G		No	ClinGen gnomAD
rs780083401 CA3887667	61	G>R		No	ClinGen ExAC TOPMed gnomAD
rs774391260 CA364694006	62	K>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	63	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1310718439 CA364693949	65	C>*		No	ClinGen gnomAD
CA3887665 rs528957645	66	R>*		No	ClinGen 1000Genomes ExAC gnomAD
rs779414355 CA3887664	66	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	67	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3887663 rs757579049	69	R>K		No	ClinGen ExAC TOPMed gnomAD
CA3887638 rs766265823	70	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1300247596 CA364692617	70	S>P		No	ClinGen TOPMed
CA140913660 rs893627537	73	S>N		No	ClinGen Ensembl
CA364692585 rs1333812665	74	M>I		No	ClinGen gnomAD
rs761526433 CA3887634	74	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1582547895 CA364692590	74	M>V		No	ClinGen Ensembl
rs373331186 CA3887633	75	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs767717346 CA140913626	76	M>K		No	ClinGen ExAC gnomAD
rs767717346 CA3887632	76	M>T		No	ClinGen ExAC gnomAD
rs1007360498 CA140913630	76	M>V		No	ClinGen TOPMed gnomAD
CA3887630 rs774462256	78	T>M	Variant assessed as Somatic; 0.0002319 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA364692550 rs1231140579	80	A>T		No	ClinGen Ensembl
rs1024166061 CA140913612	80	A>V		No	ClinGen TOPMed gnomAD
rs1413472857 CA364692544	81	L>V		No	ClinGen TOPMed gnomAD
CA3887628 rs749826107	82	S>I		No	ClinGen ExAC TOPMed gnomAD
CA3887626 rs201416149	84	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3887625 rs376978395	85	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA364692511 rs1562243606	86	W>R		No	ClinGen Ensembl
CA3887623 rs369171739	86	W>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs746548203 CA364692501	87	W>*		No	ClinGen ExAC gnomAD
rs746548203 CA3887622	87	W>S		No	ClinGen ExAC gnomAD
TCGA novel	88	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs548245687 CA140913564	88	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs548245687 CA3887621	88	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364692480 rs200533249	91	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3887619 rs200533249	91	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3887618 rs754860132	91	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA3887617 rs757105696	92	N>H		No	ClinGen ExAC TOPMed gnomAD
rs753630007 CA364692454	94	H>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	94	H>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs376745877 CA3887613	97	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA3887614 rs759735769	97	M>V		No	ClinGen ExAC TOPMed gnomAD
rs766512521 CA364692429	98	V>A		No	ClinGen ExAC TOPMed gnomAD
rs766512521 CA3887612	98	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1490187990 CA364692431	98	V>L		No	ClinGen gnomAD
rs867886156 CA140913511	101	M>I		No	ClinGen TOPMed gnomAD
rs1168449449 CA364692412	101	M>L		No	ClinGen gnomAD
CA3887610 rs550735209	102	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA3887609 rs770418612	103	E>K		No	ClinGen ExAC gnomAD
rs1247571163 CA364692386	104	D>G		No	ClinGen gnomAD
TCGA novel	105	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3887608 rs762308671	105	Q>E		No	ClinGen ExAC gnomAD
TCGA novel	106	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364692355 rs1273675337	108	L>P		No	ClinGen gnomAD
rs372154414	110	F>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs777111995 CA3887606	110	F>S		No	ClinGen ExAC gnomAD
rs1205733250 CA364692344	110	F>V		No	ClinGen gnomAD
CA3887604 rs746702488	111	G>R		No	ClinGen ExAC gnomAD
CA364692315 rs777623338	113	G>R		No	ClinGen ExAC gnomAD
rs777623338 CA3887579	113	G>S		No	ClinGen ExAC gnomAD
CA3887578 rs755951762	114	D>N		No	ClinGen ExAC gnomAD
rs752422077 CA364692291	116	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs761438108 CA140913232	116	Y>H		No	ClinGen Ensembl
TCGA novel	116	Y>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364692295 rs1582547378	116	Y>S		No	ClinGen Ensembl
rs780363800 CA3887576	117	L>R		No	ClinGen ExAC gnomAD
COSM3736425 CA3887574 rs202065785	118	R>C	skin [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs202065785 CA3887575	118	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs765437338 CA3887573	118	R>H		No	ClinGen ExAC TOPMed gnomAD
CA140913214 rs374110823	120	I>T		No	ClinGen ESP TOPMed
rs754408108 CA3887571	123	H>P		No	ClinGen ExAC gnomAD
CA3887572 rs761914474	123	H>Y		No	ClinGen ExAC gnomAD
CA3887570 rs764492118	124	S>N		No	ClinGen ExAC TOPMed gnomAD
rs761165148 CA3887569	125	H>R		No	ClinGen ExAC TOPMed gnomAD
rs775691188 CA3887568	130	L>P		No	ClinGen ExAC gnomAD
rs1562243398 CA364692201	131	E>*		No	ClinGen Ensembl
rs767252028 CA3887567 CA364692197	131	E>D		No	ClinGen ExAC gnomAD
CA3887566 rs369480492	133	W>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA3887564 rs150130213	137	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA140913131 rs150130213	137	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364692155 rs1294555769	138	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs770433424 CA3887563	139	Q>*		No	ClinGen ExAC gnomAD
rs773192554 CA3887561	141	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773192554 CA3887562	141	R>G		No	ClinGen ExAC TOPMed gnomAD
rs372741660 CA3887559	141	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA3887560 rs372741660	141	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs780872192 CA3887558	142	V>M		No	ClinGen ExAC TOPMed gnomAD
CA364692125 rs1210159353	143	T>I		No	ClinGen gnomAD
rs754762273 CA364692117	145	V>F		No	ClinGen ExAC TOPMed gnomAD
rs754762273 CA3887557	145	V>I		No	ClinGen ExAC TOPMed gnomAD
CA3887554 rs757467678	146	G>A		No	ClinGen ExAC TOPMed gnomAD
CA3887555 rs779214439	146	G>R		No	ClinGen ExAC TOPMed gnomAD
COSM3669645 CA364692110 rs757467678	146	G>V	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA140913049 rs925621462	148	H>Q		No	ClinGen TOPMed
rs1315359842 CA364692094	149	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1364482608 CA364692067	153	W>R		No	ClinGen gnomAD
rs369158621 CA3887552	153	W>S		No	ClinGen ESP ExAC
rs569098928 CA3887551	155	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA3887550 rs572106838	157	M>V		No	ClinGen ExAC gnomAD
TCGA novel	158	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3887548 rs753203314	159	C>Y		No	ClinGen ExAC gnomAD
rs181290286 CA3887547	162	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	164	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3887544 rs766005212	167	Y>C		No	ClinGen ExAC
CA3887543 rs762518328	170	A>S		No	ClinGen ExAC gnomAD
rs768333060 CA3887542	171	R>*		No	ClinGen ExAC TOPMed gnomAD
CA140912974 COSM743173 rs199949364	171	R>P	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA3887541 rs199949364	171	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1582547115 CA364691941	172	G>S		No	ClinGen Ensembl
TCGA novel	172	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3887526 rs766068547	175	M>I		No	ClinGen ExAC gnomAD
rs1483424596 CA364691912	175	M>L		No	ClinGen TOPMed
CA3887525 rs762613619	176	L>M		No	ClinGen ExAC TOPMed gnomAD
rs375224084 CA3887524	176	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA3887523 rs764657829	178	R>C		No	ClinGen ExAC TOPMed gnomAD
CA3887522 rs761326459	178	R>H		No	ClinGen ExAC TOPMed gnomAD
CA3887520 rs768707302	180	R>*		No	ClinGen ExAC TOPMed gnomAD
CA3887521 rs768707302	180	R>G		No	ClinGen ExAC TOPMed gnomAD
CA364691882 rs1418927716	180	R>P		No	ClinGen TOPMed gnomAD
rs1418927716 CA364691883	180	R>Q		No	ClinGen TOPMed gnomAD
rs1182897023 CA364691880	181	S>R		No	ClinGen gnomAD
CA364691873 rs1371797987	181	S>R		No	ClinGen TOPMed
CA364691876 rs1582546824	181	S>T		No	ClinGen Ensembl
CA364691859 rs1409918530	183	P>L		No	ClinGen TOPMed
CA364691842 rs887483060	186	N>K		No	ClinGen TOPMed
rs1056613087 CA140912676	186	N>S		No	ClinGen TOPMed gnomAD
rs199979331 CA364691840	187	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199979331 CA3887517	187	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	187	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3887516 rs775405936	189	L>R		No	ClinGen ExAC gnomAD
CA3887514 rs563152950	190	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA3887515 rs368269816	190	V>I		No	ClinGen ESP ExAC TOPMed
CA3887513 rs777989124	191	T>I		No	ClinGen ExAC TOPMed gnomAD
CA3887512 rs769778458	192	S>Y		No	ClinGen ExAC gnomAD
CA3887510 rs781617538	193	I>T		No	ClinGen ExAC gnomAD
CA3887511 rs201194392	193	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs962762004 CA140912594	194	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA364691796 rs1325917283	194	S>R		No	ClinGen gnomAD
rs200762693 CA3887508	195	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200762693 CA364691795	195	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1448651628 CA364691785	196	P>L		No	ClinGen TOPMed
rs985482455 CA140912584	197	P>L		No	ClinGen TOPMed gnomAD
rs985482455 CA364691780	197	P>R		No	ClinGen TOPMed gnomAD
TCGA novel	197	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3887507 rs780425911	199	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1242477557 CA364691767	199	T>I		No	ClinGen gnomAD
rs750055770 CA3887506	200	G>A		No	ClinGen ExAC gnomAD
CA3887505 rs750055770	200	G>E		No	ClinGen ExAC gnomAD
rs764925786 CA3887504	201	D>G		No	ClinGen ExAC gnomAD
TCGA novel	201	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364691729 rs1385811767	206	P>S		No	ClinGen TOPMed gnomAD
rs905343170 CA140912552	207	R>G		No	ClinGen Ensembl
rs1319406218 CA364691724	207	R>K		No	ClinGen gnomAD
CA3887502 rs753354797	207	R>S		No	ClinGen ExAC gnomAD
rs1171459251 CA364691720	208	I>V		No	ClinGen TOPMed
rs764172574 CA364691713	209	S>G		No	ClinGen ExAC TOPMed gnomAD
CA364691711 rs1160697933	209	S>N		No	ClinGen gnomAD
rs764172574 CA3887501	209	S>R		No	ClinGen ExAC TOPMed gnomAD
CA3887500 rs148053198	211	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs201705217 CA140912547	211	T>I		No	ClinGen 1000Genomes
CA364691695 rs367849614	212	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs367849614 CA3887498	212	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1433374915 CA364691686	213	C>F		No	ClinGen TOPMed
rs1462664535 CA364691690	213	C>R		No	ClinGen gnomAD
CA364691678 rs1246286601	214	L>R		No	ClinGen gnomAD
rs377447679 CA3887497	215	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1208300634 CA364691676	215	S>R		No	ClinGen gnomAD
CA3887495 rs373674170	216	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	216	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1355551928 CA364691637	221	P>H		No	ClinGen gnomAD
rs748218067 CA3887494	221	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1228448344 CA364691613	224	V>A		No	ClinGen gnomAD
TCGA novel	226	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs955895713 CA140912445	226	G>V		No	ClinGen TOPMed gnomAD
CA3887491 rs780480838	227	C>F		No	ClinGen ExAC TOPMed gnomAD
CA3887490 rs780480838	227	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA3887489 rs377743187	228	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs186941657 CA3887487	229	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs186941657 CA364691585	229	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1390476906 CA364691563	232	L>F		No	ClinGen gnomAD
TCGA novel	232	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA140912428 rs778100429	233	S>N		No	ClinGen Ensembl
CA3887485 rs753386664	234	S>L		No	ClinGen ExAC gnomAD
rs1467142886 CA364691545	235	L>P		No	ClinGen TOPMed
rs1388366304 CA567683304	236	Y>*		No	ClinGen gnomAD
rs538554497 CA3887484	237	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs538554497 CA3887483	237	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with Q4VXA5

7 regional properties for Q4VXA5

Type	Name	Position	InterPro Accession
domain	PKD domain	523 - 592	IPR000601
domain	MANSC domain	49 - 127	IPR013980
domain	PKD/Chitinase domain	312 - 401	IPR022409-1
domain	PKD/Chitinase domain	409 - 498	IPR022409-2
domain	PKD/Chitinase domain	504 - 594	IPR022409-3
domain	PKD/Chitinase domain	600 - 688	IPR022409-4
domain	PKD/Chitinase domain	694 - 785	IPR022409-5

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name	Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MLSAFQRLFR	VLFVIETVSE	YGVLIFIYGW	PFLQTLAMLL	IGTVSFHLWI	RRNRERNSRS
70	80	90	100	110	120
GKTRCRSKRS	EQSMDMGTSA	LSKKPWWTLP	QNFHAPMVFH	MEEDQEELIF	GHGDTYLRCI
130	140	150	160	170	180
EVHSHTLIQL	ESWFTATGQT	RVTVVGPHRA	RQWLLHMFCC	VGSQDSYHHA	RGLEMLERVR
190	200	210	220	230
SQPLTNDDLV	TSISVPPYTG	DLSLAPRISG	TVCLSVPQPS	PYQVIGCSGF	HLSSLYP