Q4VBI7

PR
Gene name
stx18
Protein name
Syntaxin-18
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:554130
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4VBI7

Entry ID Method Resolution Chain Position Source
AF-Q4VBI7-F1 Predicted AlphaFoldDB

No variants for Q4VBI7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4VBI7

No associated diseases with Q4VBI7

2 regional properties for Q4VBI7

Type Name Position InterPro Accession
conserved_site Syntaxin/epimorphin, conserved site 228 - 268 IPR006012
domain SNARE-complex protein Syntaxin-18, N-terminal 4 - 95 IPR019529

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type IV membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
SNARE complex A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.

1 GO annotations of molecular function

Name Definition
SNAP receptor activity Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.

2 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41834 UFE1 Syntaxin UFE1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MAADITLLFK ASVKTVKTRN KALGLMETTG REEPGAQKRP RPRQRDSFSC KAREVISNIS
70 80 90 100 110 120
KLKDFLLQHR KDYVNAGSVM SSEVSRMTDS ERDQIDQDAQ IFMRTCAEAI SQLRSEMDKK
130 140 150 160 170 180
QVSMQVKDHR AAVLDLIDSY LKGVCKLYSE QRAVRVKRVV DKKRLSRLEP EQINTEKRQS
190 200 210 220 230 240
DGEENDKPVS DGNVDLWEEN RVEDDLSPEE IQMFEQENQR LVGEMNSLLD EVRQIEGKVV
250 260 270 280 290 300
EISRLQEIFS EKVLQQETEI DSIHQLVVGA TENVKEGNED IREAIKNNAG FRVWILFFLV
310
MCSFSLLFLD WYDS