Q4VBE8
Gene name |
Wdr18 |
Protein name |
WD repeat-containing protein 18 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:216156 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4VBE8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4VBE8-F1 | Predicted | AlphaFoldDB |
14 variants for Q4VBE8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389123633 | 26 | H>Q | No | EVA | |
| rs3400728599 | 48 | N>Y | No | EVA | |
| rs3389112922 | 63 | C>S | No | EVA | |
| rs3389111530 | 69 | R>H | No | EVA | |
| rs3389109419 | 95 | V>A | No | EVA | |
| rs3389111713 | 173 | L>I | No | EVA | |
| rs3389109460 | 190 | A>G | No | EVA | |
| rs3389111541 | 247 | W>R | No | EVA | |
| rs3389118407 | 263 | K>E | No | EVA | |
| rs3389086299 | 291 | E>* | No | EVA | |
| rs3389100833 | 380 | Q>P | No | EVA | |
| rs227551048 | 396 | M>I | No | EVA | |
| rs3389079102 | 418 | L>Q | No | EVA | |
| rs3389114446 | 431 | K>M | No | EVA |
No associated diseases with Q4VBE8
9 regional properties for Q4VBE8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 70 - 107 | IPR001680-1 |
| repeat | WD40 repeat | 110 - 150 | IPR001680-2 |
| repeat | WD40 repeat | 161 - 243 | IPR001680-3 |
| repeat | WD40 repeat | 258 - 306 | IPR001680-4 |
| conserved_site | WD40 repeat, conserved site | 284 - 298 | IPR019775 |
| repeat | G-protein beta WD-40 repeat | 136 - 150 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 189 - 203 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 284 - 298 | IPR020472-3 |
| domain | WD repeat-containing protein 18, C-terminal domain | 383 - 429 | IPR026987 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| dynein axonemal particle | An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm. |
| nuclear pre-replicative complex | A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| Rix1 complex | A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BV38 | WDR18 | WD repeat-containing protein 18 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPMEVVVC | TDAAAQLWSC | VVWELHSGAN | LLTYRGGQAG | PRGLALLNGE | YLLAAQQGKN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YICAWELQRK | DQLQQKIMCP | GPVTCLTTAP | NGLYVLAGIA | ESIYLWEVCT | GNLLVILSRH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YQDVSCLKFT | GDGSHFVSAG | KDCLALAWSL | CSVLQADPSR | ILAPRHVWSQ | HTLPITDLHC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GFGGPMARVA | TASLDQTVKL | WAISSGDLLL | SVLFDMGITS | VTMDLAEHHI | FCGGSDGSIF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QVDLCSWPGL | REHSFQPEQN | TGKVFKGHRN | QVTCLSVSTD | GSVLLSGSHD | ESVRLWDVKS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KQCLRTVTLK | GPVTNAAIIL | APPSMLNPEF | RPSLPLPHFN | KHLLGAEHGD | EAQGGGLRLQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGLHLQGKEP | SYLERLEQLQ | AVLSSYLEKN | MLGSQMLPAR | VFDLEDEVRS | LRKINRDLFD |
| 430 | |||||
| FSTRIITRPS | K |