Q4V8G2
Gene name |
Eid3 |
Protein name |
EP300-interacting inhibitor of differentiation 3 |
Names |
EID-3, E1A-like inhibitor of differentiation 3, EID-1-like inhibitor of differentiation 3, Non-structural maintenance of chromosomes element 4 homolog B, NS4EB, Non-SMC element 4 homolog B |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:691688 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4V8G2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4V8G2-F1 | Predicted | AlphaFoldDB |
No variants for Q4V8G2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4V8G2 | |||||
No associated diseases with Q4V8G2
No regional properties for Q4V8G2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q4V8G2 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Smc5-Smc6 complex | A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEEKCSLTG | GEEKGEELAR | SLAWQHLVKQ | AEEDDDDDEE | ALKKEEEEEE | EEEEEDEEEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEGPDSSSDD | LSPEAPCMHP | DLLELAVDRE | KCRSIRRQYR | QLIYTVQQNR | EDIVNTASDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LTEALEEANV | LFDGVSRTRE | AALDAQFLVL | ASDLGKEKAK | QLNSDMSFFN | HVAFCELLLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FVGLNWMEEE | CEELSECDES | IALSFWNMLH | KEATAWMLQA | ETFHFIFGSF | KAERSARKPR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QEHHKRACKM | EGNGDMPTKL | RKLDVHANQE | TTEKEVERIL | GLLQTYFQKY | PDTPVSYFEF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VIDPNSFSRT | VENIFYVSFI | IRDGFARIRL | DQDRLPILEP | TNVNQVDEEN | DSCSYCRKQG |
| 370 | 380 | ||||
| VISLSLQDWK | NIVSTFEISE | AMIKNSY |