Q4UND5

PR
Gene name
waaA (kdtA, RF_0072)
Protein name
3-deoxy-D-manno-octulosonic acid transferase
Names
Kdo transferase, Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
Species
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
KEGG Pathway
rfe:RF_0072
EC number
2.4.99.12: Transferring other glycosyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

28-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4UND5

Entry ID Method Resolution Chain Position Source
AF-Q4UND5-F1 Predicted AlphaFoldDB

No variants for Q4UND5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4UND5

No associated diseases with Q4UND5

2 regional properties for Q4UND5

Type Name Position InterPro Accession
domain Rickettsial palindromic element 1 51 - 93 IPR005728
domain 3-deoxy-D-manno-octulosonic-acid transferase, N-terminal 94 - 254 IPR007507

Functions

Description
EC Number 2.4.99.12 Transferring other glycosyl groups
Subcellular Localization
  • Cell inner membrane ; Single-pass membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
Kdo transferase activity Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP.

1 GO annotations of biological process

Name Definition
lipopolysaccharide core region biosynthetic process The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMLLYYALSF ILLPIYFIII LIRLLIGKED IRRIQERFAI GKHRQVYSLD FLHNEANKER
70 80 90 100 110 120
FKGDTERRTA AYTSVREDSS TGSTSKLPLE ASYARSLIWI HAASVGESMA ALTLISNISK
130 140 150 160 170 180
RYPDIRFLVT SWTNSSAKIL TAKLPKIAVH QFLPIDNIIF TRKFLKNWQP NLGIFIESEL
190 200 210 220 230 240
WPCTINEGAR QCKLLLVNAR ISDKSFKAWL KRKSFFQLIL KNFSKIIVQS ERDLQKFNEL
250 260 270 280 290 300
GISDAINLGN IKFANEKLPV NQEELSKLSS HLDNRQVVVF ASTHPEDEEV ILPIIKNLKE
310 320 330 340 350 360
QFLDCYIILI PRHPERVKSI IDNCKSHNLS ATAKSQNDLP VLSDDIYIVD RFGEMGLFFS
370 380 390 400 410 420
VATISFIGGS FKQGGHNILE AAYFSNCIIF GPDMSKNTDI AKGVLQNEAA IQIKNGEDLL
430 440 450 460
TKLTYLLSPN NSLELKAYRE NALKFVENNQ KVLDEYLQVI TKFL