Q4UN61

PR
Gene name
tsaD
Protein name
tRNA N6-adenosine threonylcarbamoyltransferase
Names
N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Species
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
KEGG Pathway
rfe:RF_0146
EC number
2.3.1.234: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

254-333 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4UN61

Entry ID Method Resolution Chain Position Source
AF-Q4UN61-F1 Predicted AlphaFoldDB

No variants for Q4UN61

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4UN61

No associated diseases with Q4UN61

3 regional properties for Q4UN61

Type Name Position InterPro Accession
domain Gcp-like domain 3 - 387 IPR000905
conserved_site Peptidase M22, conserved site 97 - 117 IPR017860
domain Rickettsia palindromic element RPE3 274 - 316 IPR022437

Functions

Description
EC Number 2.3.1.234 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
iron ion binding Binding to an iron (Fe) ion.
N(6)-L-threonylcarbamoyladenine synthase activity Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA.

1 GO annotations of biological process

Name Definition
tRNA threonylcarbamoyladenosine modification The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIKILGIESS CDDTAVSIIT ENREILSNII ISQNTEHAVF GGVVPEIAAR SHLSNLDKAL
70 80 90 100 110 120
KNVLKESNTK LTEISAIAAT SGPGLIGGVI VGSMFARSLS SAFKKPFIAI NHLEGHALTA
130 140 150 160 170 180
RLTDNIPYPY LLLLASGGHC QFVAVLGLGK YKILGSTIDD AIGEAFDKVA KMLNLAFPGG
190 200 210 220 230 240
PEIEKRAKLG DPHKYKFPKP IINSGNCNMS FSGLKTAVRT LIMSLKELND AVINDIAASF
250 260 270 280 290 300
QFTIGEILSS KVQDAIIAYE RVVNDYYENI DYTTQLNLKS FRQDEFKEEP AEHTKVREHR
310 320 330 340 350 360
LYPQNSLGSS FLNDAIVIAG GVAANKYLQE ILSNCAKTYG YQLIYPPIRL CTDNAAMIAY
370 380
AGLERYNNKL FTPLNFCPKA RWSLEDISK