Q4ULG1

PR
Gene name
pdhC (RF_0761)
Protein name
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Names
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2
Species
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
KEGG Pathway
rfe:RF_0761
EC number
2.3.1.12: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

48-221 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4ULG1

Entry ID Method Resolution Chain Position Source
AF-Q4ULG1-F1 Predicted AlphaFoldDB

No variants for Q4ULG1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4ULG1

No associated diseases with Q4ULG1

4 regional properties for Q4ULG1

Type Name Position InterPro Accession
domain Biotin/lipoyl attachment 2 - 78 IPR000089
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 184 - 411 IPR001078
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 27 - 56 IPR003016
domain Peripheral subunit-binding domain 131 - 169 IPR004167

Functions

Description
EC Number 2.3.1.12 Transferring groups other than amino-acyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).

1 GO annotations of molecular function

Name Definition
dihydrolipoyllysine-residue acetyltransferase activity Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.

2 GO annotations of biological process

Name Definition
acetyl-CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPIKILMPVL SPTMTEGNLA RWLKKEGDKV NPGEVIAEIE TDKATMEVEA VDEGILAKIV
70 80 90 100 110 120
IPQNSQNVPV NSLIAVLSEE GEEKTDIDAF IAKNNNVSPS PKTDANLPKP HENIAKVEEQ
130 140 150 160 170 180
VAVIKHDASK IFASPLAKRL AKMGNIRLES VKGSGPHGRI VKQDILSYTP STVHNKIVSR
190 200 210 220 230 240
NPEEYRLVPN NNIRKIIAKR LLESKQTVPH FYLSIECNVD KLLDIREDIN KSFSEDKSTR
250 260 270 280 290 300
ISVNDFIILA VAKALQELPN ANASWGEDAI RYHNNVDISV AVAIENGLVT PIVKNANQKN
310 320 330 340 350 360
IIELSREMKE LIKKAKDNKL TPEEFQGGGF TISNLGMYGI KNFNAIINPP QSCIMGVGAS
370 380 390 400 410
AKRAIVKNDQ VTIATIMDVT LSADHRVVDG AVGAEFLAAF KKFIESPALM LI