Q4UK40

PR
Gene name
dnaE (RF_1244)
Protein name
DNA polymerase III subunit alpha
Names
Species
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
KEGG Pathway
rfe:RF_1244
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

685-756 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4UK40

Entry ID Method Resolution Chain Position Source
AF-Q4UK40-F1 Predicted AlphaFoldDB

No variants for Q4UK40

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4UK40

No associated diseases with Q4UK40

5 regional properties for Q4UK40

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 6 - 73 IPR003141
domain PHP domain 7 - 170 IPR004013
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 290 - 569 IPR011708
domain DNA polymerase, helix-hairpin-helix motif 807 - 957 IPR029460
domain DNA polymerase III alpha subunit finger domain 572 - 734 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRPEFIHLRT QSSYSFLESA LTIEKVVELA SSNKMPAICL ADKGNLFGSL EFALYAVKKG
70 80 90 100 110 120
LQPIHGVILN IKYDIDIFAQ ILLIAKDETG YKNLLKLSSL TFTKNDRKLC DHIDFEDLIE
130 140 150 160 170 180
YQEGLIALCC YTDGIVGKCL LARSEEQAML FARKLQDILG DRFYFEIMRH DLPEEQFIED
190 200 210 220 230 240
SYIRIAAELA IPLVATNKVL FSEKTMHDAH DVLLCISAGV TKEYPDRKTV SENCYFRSPH
250 260 270 280 290 300
EMIELFSDLP SAIQNTVNLR ERCYFAAHAN PPMLPNFATK DISETDLIRK DAKEGLLARL
310 320 330 340 350 360
ATKFKSENIP LQNQEELKTE YFARLNYELD IICNMNFAGY FLIVSDFIKW SKKEGILVGP
370 380 390 400 410 420
GRGSGAGSVV AWSLLITDLD PIKFGLLFER FLNPERISMP DFDIDFCQER REEVINYVRS
430 440 450 460 470 480
KYGNNRVGQI ITFGKMQAKA VIKDVARVLS LPYKFADYLT ELVPFSAVNP VSLEQAMREV
490 500 510 520 530 540
PELANAAKGN GLYNLEGEAE LIKLVLDTSL ILEGLHRHSS THAAGIVIAG TDLVDIVPVY
550 560 570 580 590 600
KDANSDMLVV GYSMKYSEIA GLIKFDFLGL QTLTVITDCK KLLKEQGIEV DFNNMTFDDN
610 620 630 640 650 660
KTYQMLCKGK GVGVFQFESI GMKDALRRLK PDSIHDLIAL GALYRPGPME NIPTYIACKH
670 680 690 700 710 720
KLQQPDYLHE LLKPILEETY GVVIYQEQVQ RIAQILAGYT LGAADLLRRA MGKKIKKEME
730 740 750 760 770 780
EQEEIFVKGA IANNISESQA KSIFATVAKF AGYGFNKAHA AAYGVISYQT AYLKANYPAE
790 800 810 820 830 840
FLVACLNLEL NNHDKINLFL QEAKDSGIKI IAPNINISEG YFSVKSVIPQ AATCHPQGPL
850 860 870 880 890 900
CHPRVGGYPE KVKTVLNHES MKMDSRFCGN DIKGSRNDIE DTGYDKEKST IIFALGAIKG
910 920 930 940 950 960
VTPNFGKLVT DERKARGAFK SITDFIERLP LKSINSKLLE NLIKSGCFDE LHDNRLQLFS
970 980 990 1000 1010 1020
SISKLLAYSA SYHAEQESNQ FSLIKVSSLS PNILIASDYA DNNTLAFYEF ESMGLFISNH
1030 1040 1050 1060 1070 1080
PLTQYQEIFS RLNILNTADL HNNLPDGTNR VNLAGVIQKK DSRMSARGRF VTLVLSDPEN
1090 1100 1110 1120 1130 1140
IFELSIFSEE VLKDYVHLLD VKSLVVVNCD IVKDEGGIKL TAKSFSSIED AINNKQFELQ
1150 1160 1170 1180 1190 1200
LYPQNHEELR QIVTLLAART NNRDQSNAKA TIYLQSEGVK NFVAKITLPE KFFLQGQDFE
ILKGYSK