Q4UIN6

PR
Gene name
TA16990
Protein name
Translation factor GUF1 homolog, mitochondrial
Names
Elongation factor 4 homolog, EF-4, GTPase GUF1 homolog, Ribosomal back-translocase
Species
Theileria annulata
KEGG Pathway
tan:TA16990
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

656-730 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4UIN6

Entry ID Method Resolution Chain Position Source
AF-Q4UIN6-F1 Predicted AlphaFoldDB

No variants for Q4UIN6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4UIN6

No associated diseases with Q4UIN6

6 regional properties for Q4UIN6

Type Name Position InterPro Accession
domain Elongation factor EFG, domain V-like 522 - 619 IPR000640
domain Translational (tr)-type GTP-binding domain 106 - 289 IPR000795
domain Small GTP-binding protein domain 110 - 281 IPR005225
domain GTP-binding protein LepA, C-terminal 622 - 704 IPR013842
conserved_site Tr-type G domain, conserved site 146 - 161 IPR031157
domain Elongation Factor G, domain II 414 - 488 IPR041095

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
ribosome binding Binding to a ribosome.

2 GO annotations of biological process

Name Definition
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLYKYLFIYI VTKISLSSSL YHNFCTINNT NGSNFNVFDT NNGRFLNKNN RIRNILNKNI
70 80 90 100 110 120
NKKSSFSFIN GNSLKNFKND HKYHDFTKFT KIPEFLEEDN EPIVSELIRN FCIIAHVDHG
130 140 150 160 170 180
KSTLADRFLE FTKSVPPERL KEQYLDNMEL ERERGITIKL QSARIKYNSI LDGKTYTLNL
190 200 210 220 230 240
IDTPGHIDFN HEARRSISAC EGAILVVDGT KGIEAQTVTT ANIAIEKGLK IIPVVNKIDL
250 260 270 280 290 300
EHCDFKSTAE SLKKFFGFKE SDILKASAKK GIGIEDILEA VVVSIPPPKV DLEKPFRALV
310 320 330 340 350 360
FDSFYDPYRG AICYIRVCCV FRLYFQVFEG STKIGDEITL MNADITSKVT GLGIMLPEMK
370 380 390 400 410 420
QTHSLQLVNS SGQVGWITAG IKKTNEIHVG DTISLKSYVK KNLVEPINKF ENSKPTVFAG
430 440 450 460 470 480
IYPCIGGDFD KLQTALEKLK LNDHSFQFER SDSSMVGMGF KCGFNGLLHL DITVERLERE
490 500 510 520 530 540
FDTQVIVTSP SVPYRCTLRD KSVVTVDDAS KWPDESQIKS SEEPWTDVTL RVPEEYFLSF
550 560 570 580 590 600
INIILSSVGS VMSMLSKMRG RFKEKNKVKD TNMVVMNYDL PLSEILSDFF NKLKSVTNGY
610 620 630 640 650 660
GSYDYEGTFY EPIELCKLKI LLNGTEAKGL AVVTPRNRAY DRGKLIVETL VNLIPSRQFK
670 680 690 700 710 720
VPVQAVIGKR VISSSNIPAV KKNVIEKCSG GDPSRKKKLL ENQARVLLVL INDVIGKETN
GSGRMCNNPF