Q4SBY6
Gene name |
hnmt (GSTENG00020755001) |
Protein name |
Histamine N-methyltransferase |
Names |
HMT |
Species |
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) |
KEGG Pathway |
tng:GSTEN00020755G001 |
EC number |
2.1.1.8: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4SBY6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4SBY6-F1 | Predicted | AlphaFoldDB |
No variants for Q4SBY6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4SBY6 | |||||
No associated diseases with Q4SBY6
No regional properties for Q4SBY6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q4SBY6 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.8 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| histamine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| histamine catabolic process | The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASAMRSLIE | DDSRYLKSFK | LFLERSTEHQ | CVQEFIHNVL | PDILGSVGKG | KTHLNVIGVG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGAGEVDLEI | LSELHSRHPG | ASVDNEVVEP | SAQQLQDYKA | LVLQKKDLDY | ISFNWNKMTA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TEFEERWRAN | KMSKEADFIH | MIQMLYYVKD | PEATTSFFQS | LLSKTGKLLI | ILVSGNSGWG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLWKTYKNQF | CNPEISQCVT | TADIQSFLDS | KGARYQSFEL | PSQMDITECF | TQGDEKGELL |
| 250 | 260 | 270 | 280 | 290 | |
| LDFLTEVLEF | SKTASPELRA | EVMELLRHPD | CSVESNGRVM | FNNNLGVIVL | D |