Q4R945

PR
Gene name
TTK (QtsA-10742)
Protein name
Dual specificity protein kinase TTK
Names
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

350-543 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

662-687 (Activation loop from InterPro)

Target domain

524-790 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q4R945

Entry ID Method Resolution Chain Position Source
AF-Q4R945-F1 Predicted AlphaFoldDB

No variants for Q4R945

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4R945

No associated diseases with Q4R945

4 regional properties for Q4R945

Type Name Position InterPro Accession
domain Protein kinase domain 524 - 790 IPR000719
active_site Serine/threonine-protein kinase, active site 642 - 654 IPR008271
binding_site Protein kinase, ATP binding site 530 - 552 IPR017441
domain Protein kinase Mps1 family, catalytic domain 522 - 790 IPR027084

Functions

Description
EC Number 2.7.12.1 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

2 GO annotations of biological process

Name Definition
chromosome separation The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).
organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MESEDLSGRE LTIDSIMNKV RDIKNKFKNE DLTDELSLNK ISADTTDNSG TVNQIMMMAN
70 80 90 100 110 120
SPEDWLSLLL KLEKNSVPLS DALLNKLIGR YSQAIEALPP DKYGQNESFA RIQVRFAELK
130 140 150 160 170 180
AIQEPDDARD YFQMARANCK KFAFVHISFA QFELSQGNVK KSKQLLQEAV ERGAVPLEML
190 200 210 220 230 240
EIALRNLNLQ KKQLLSEEEK KTLSASMVLT AQESFSSSLG HLQNRNNSCD SRGQTTKARF
250 260 270 280 290 300
LYGENMPPQD AEIGYRNSLK QTNKTKQSCP FGRVPVNLLN SPDCDVKTDD SVVPCFIKRQ
310 320 330 340 350 360
TSRSECRDLV VAGSKPSGND SCELRNLKSV QNINCKEPLV SDEKSSELII TDSVTLKNKT
370 380 390 400 410 420
ESSLRAKLEE TKEYQEPEVP ESNQKQWQSK RKSACINENP VASSNQWQIP ELARKVNIEK
430 440 450 460 470 480
HTTFEQPVFS VSKQSPPMSA SKWFDPKSIC KTPSSNTLDD YMSCFRTPVV KNDFPPACQL
490 500 510 520 530 540
STPYGQPACF QQQQQQIPAT PLQNLQVLAS SSANECISVK GRIYSILKQI GSGGSSKVFQ
550 560 570 580 590 600
VLNEKKQIYA IKFVNLEEAD NQTLDSYRNE IAYLNKLQQH SDKIIRLYDY EITDQYIYMV
610 620 630 640 650 660
MECGNIDLNS WLKKKKSIDP WERKSYWKNM LEAVHTIHQH GIVHSDLKPA NFLIVDGMLK
670 680 690 700 710 720
LIDFGIANQM QPDTTSIVKD SQVGTVNYMP PEAIKDMSSS RENGKSKSKI SPKSDVWSLG
730 740 750 760 770 780
CILYYMTYGK TPFQHIINQI SKLHAIIDPN HEIEFPDIPE KDLQDVLKCC LKRDPKQRIS
790 800 810 820 830 840
IPELLAHPYV QIQTHPGNQM AKGTTEEMKY VLGQLVGLNS PNSILKAAKT LYEHYSGGES
850
HNSSSSKTFG KKREKK