Q4R8K5
Gene name |
EIF4A1 (QtsA-12280) |
Protein name |
Eukaryotic initiation factor 4A-I |
Names |
eIF-4A-I, eIF4A-I, ATP-dependent RNA helicase eIF4A-1 |
Species |
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
KEGG Pathway |
|
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4R8K5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4R8K5-F1 | Predicted | AlphaFoldDB |
No variants for Q4R8K5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4R8K5 | |||||
No associated diseases with Q4R8K5
6 regional properties for Q4R8K5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 180 - 188 | IPR000629 |
| domain | Helicase, C-terminal | 245 - 406 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 57 - 221 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 51 - 249 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 32 - 60 | IPR014014 |
| domain | ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain | 34 - 235 | IPR044728 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSASQDSRSR | DNGPDGMEPE | GVIESNWNEI | VDSFDDMNLS | ESLLRGIYAY | GFEKPSAIQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RAILPCIKGY | DVIAQAQSGT | GKTATFAISI | LQQIELDLKA | TQALVLAPTR | ELAQQIQKVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MALGDYMGAS | CHACIGGTNV | RAEVQKLQME | APHIIVGTPG | RVFDMLNRRY | LSPKYIKMFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LDEADEMLSR | GFKDQIYDIF | QKLNSNTQVV | LLSATMPSDV | LEVTKKFMRD | PIRILVKKEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LTLEGIRQFY | INVEREEWKL | DTLCDLYETL | TITQAVIFIN | TRRKVDWLTE | KMHARDFTAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AMHGDMDQKE | RDVIMREFRS | GSSRVLITTD | LLARGIDVQQ | VSLVINYDLP | TNRENYIHRI |
| 370 | 380 | 390 | 400 | ||
| GRGGRFGRKG | VAINMVTEED | KRTLRDIETF | YNTSIEEMPL | NVADLI |