Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4R7Z9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4R7Z9-F1 | Predicted | AlphaFoldDB |
No variants for Q4R7Z9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4R7Z9 | |||||
No associated diseases with Q4R7Z9
5 regional properties for Q4R7Z9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Tetratricopeptide repeat | 57 - 90 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 91 - 124 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 151 - 184 | IPR019734-3 |
| repeat | Tetratricopeptide repeat | 230 - 263 | IPR019734-4 |
| repeat | Tetratricopeptide repeat | 461 - 494 | IPR019734-5 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| intraciliary transport particle B | The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| intraciliary transport particle B binding | Binding to an intraciliary transport particle B (IFT B) complex. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| axoneme assembly | The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. |
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| intraciliary transport | The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. |
| manchette assembly | The aggregation, arrangement and bonding together of a set of components to form a manchette. |
| protein localization to cilium | A process in which a protein is transported to, or maintained in, a location within a cilium. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| smoothened signaling pathway | The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMLSRAKPAV | GRGVQPTDKK | KKKGRKIPKL | EELLSKRDFT | GAITLLEFKR | HVGEEEEDTN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LWIGYCAFHL | GDYKRALEEY | ENATKEENCN | SEVWVNLACT | YFFLGMYKQA | EAAGFKASKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLQNRLLFHL | AHKFNDEKKL | MSFHQNLQDV | TEDQLSLASI | HYMRSHYQEA | IDIYKRILLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NREYLALNVY | VALCYYKLDY | YDVSQEVLAV | YLQQIPDSTI | ALNLKACNHF | RLYNGRAAEA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELKSLMDNAS | SSFEFAKELI | RHNLVVFRGG | EGALQVLPPL | VDVIPEARLN | LVIYYLRQDD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VQEAYNLIKD | LEPTTPQEYI | LKGVVNAALG | QEMGSRDHMK | IAQQFFQLVG | GSASECDTIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GRQCMASCFF | LLKQFDDVLI | YLNSFKSYFY | NDDIFNFNYA | QAKAATGNTS | EGEEAFLLIQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SEKMKNDYIY | LSWLARCYIM | NKKPRLAWEL | YLKMETSGES | FSLLQLIAND | CYKMGQFYYS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AKAFDVLERL | DPNPEYWEGK | RGACVGIFQM | IVAGREPKET | LREVLHLLRS | TGNTQVEYMI |
| 550 | |||||
| RIMKKWAKEN | RVPI |