Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4R7U4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4R7U4-F1 | Predicted | AlphaFoldDB |
No variants for Q4R7U4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4R7U4 | |||||
No associated diseases with Q4R7U4
5 regional properties for Q4R7U4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | TolB, N-terminal | 23 - 120 | IPR007195 |
| repeat | WD40-like beta propeller | 197 - 221 | IPR011659-1 |
| repeat | WD40-like beta propeller | 235 - 270 | IPR011659-2 |
| repeat | WD40-like beta propeller | 280 - 313 | IPR011659-3 |
| repeat | WD40-like beta propeller | 368 - 396 | IPR011659-4 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
| transcription factor TFIIH holo complex | A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. |
| transcription factor TFIIK complex | A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYHNSSQKRH | WTFSSEEQLA | RLRADANRKF | RCKAVANGKV | LPNDPVFLEP | HEEMTLCKYY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKRLLEFCSV | FKPAMPRSVV | GTACMYFKRF | YLNNSVMEYH | PRIIMLTCAF | LACKVDEFNV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSPQFVGNLR | ESPLGQEKAL | EQILEYELLL | IQQLNFHLIV | HNPYRPFEGF | LIDLKTRYPI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LENPEILRKT | ADDFLNRIAL | TDAYLLYTPS | QIALTAILSS | ASRAGITMES | YLSESLMLRE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NRTCLSQLLD | IMKSMRNLVK | KYEPPRSEEV | AVLKQKLERC | HSAELALNVI | TKKRKGYEDD |
| 310 | 320 | ||||
| DYVPKKSKHE | EEEWTDDDLV | ESL |